. The American journal of roentgenology, radium therapy and nuclear medicine . icroscopical examination of muscleshowed round cell infiltration with forma-tion of fibrous tissue and atrophy of themuscular fibers. In one of the large ves-sels was a soft white thrombus adherentto the wall on microscopical examination,showing it to be composed of blood andfibrin. Section of the bone at the site offracture showed the trebeculae rather thinand medullary spaces filled with rather afibrous tissue in places with considerableround cell infiltration. In one area therewere numerous large multinucleated b
. The American journal of roentgenology, radium therapy and nuclear medicine . icroscopical examination of muscleshowed round cell infiltration with forma-tion of fibrous tissue and atrophy of themuscular fibers. In one of the large ves-sels was a soft white thrombus adherentto the wall on microscopical examination,showing it to be composed of blood andfibrin. Section of the bone at the site offracture showed the trebeculae rather thinand medullary spaces filled with rather afibrous tissue in places with considerableround cell infiltration. In one area therewere numerous large multinucleated bodiessuggesting osteoclasts. From the study ofthe preparations up to the present time,differential diagnosis seems to be betweenan inflammatory process and one of the trophic disturbances. There is no indication of a new growth. 16,4-139. I saw the other case only in consultationand I shall not report it in detail, as thefindings were not complete. After a review of the literature and studyof all the plates I was able to obtain oncases of osteogenesis imperfecta, fragilitus. Fig. 6. Case Diagnosed Clinically as Osteomalacia*j Its appearance is atypical. There is proliferationas well as destruction of bone taking place. The de-structive process apparently predominates. ossium, osteomalacia and Pagets disease,I feel that there are two distinct types ofthe disease—a hyperplastic and a hypo-plastic with various gradations between—and that it may occur either in adults orin children. It seems to me that these cases couldbe grouped together roentgenographically Osteomalacia 511 even more easily than pathologically,classing them all osteomalacia as vonRecklinghausen has done. In the hypoplastic group in children arethe cases generally classed as osteogenesisimperfecta or fragilitus ossium. In thesecases there is loss of lime salts and thinningof the cortex which produces a diminutionin density. The trabecule remain in the size or shape of the bonesdoes not occur unle
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