. Carnegie Institution of Washington publication. 12 Papers from the Department of Marine Biology. appears to be that of acidosis in blood, wherein pathological effects appear when the amount of acid is so slight that the PH is hardly affected, the buffer value of the carbonates and phosphates, however, being reduced. It was due, indeed, to the acidity of the distilled water, and to my not realizing the marked effect of slight changes in temperature, that I was misled into entertaining the false idea that the curve of decline in rate in diluted sea-water resembles that of Freundlich's curve of
. Carnegie Institution of Washington publication. 12 Papers from the Department of Marine Biology. appears to be that of acidosis in blood, wherein pathological effects appear when the amount of acid is so slight that the PH is hardly affected, the buffer value of the carbonates and phosphates, however, being reduced. It was due, indeed, to the acidity of the distilled water, and to my not realizing the marked effect of slight changes in temperature, that I was misled into entertaining the false idea that the curve of decline in rate in diluted sea-water resembles that of Freundlich's curve of adsorption, and that therefore adsorption may play a fundamental role in nerve-conduction. These recent experiments, wherein the sea-water 100. 50 1007* 90 80 70 60 Concentration of diluted sea water •Electrical conductivity. -o Rate when natural sea-water is diluted with acid distilled water of PH • Rate when natural sea-water is diluted with alkaline distilled water of PH FIG. 8.—Showing decline in rate of nerve-conduction in Cassiopea in diluted sea-water, and corresponding decline in the electrical conductivity of sea-water. See tables 4 and 5. was diluted with distilled water of PH about 8, appear to show that adsorption has nothing to do with the matter. Indeed, Ralph S. Lillie (1916)* has already called attention to the close resemblance between my curve for decline in rate of nerve-con- duction and the corresponding decline in the electrical conductivity of the*diluted sea-water, and in this latest and best-established curve of 1916, using distilled water of about PH 8 to dilute the sea-water, the accordance with Lillie's expectation is almost perfect, as appears from table 5 and figure 8. It should be said, however, that the degree of ionization of the sodium, calcium, and potassium of the sea-water follows nearly the same law. Thus the rate of nerve-conduction, as *American Journal of Physiology, vol. 41, pp. Please note that these images
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