. Colchicine in agriculture, medicine, biology, and chemistry. Colchicine; Colchicine. 784 Colchicine per cent of all the nucleated cells of the marrow were arrested at ;" That this actually decreases the output of young red blood cells was made clear by reticulocyte counts in the blood of rabbits. Normal animals and rabbits with phenylhydrazine-induced hemolytic anemia were utilized (Fig. and ). A sharp but transient iall in the percentage of reticulocytes is a convincing demon- stration ol the inhibition of blood 7 I 6 I 5 _
. Colchicine in agriculture, medicine, biology, and chemistry. Colchicine; Colchicine. 784 Colchicine per cent of all the nucleated cells of the marrow were arrested at ;" That this actually decreases the output of young red blood cells was made clear by reticulocyte counts in the blood of rabbits. Normal animals and rabbits with phenylhydrazine-induced hemolytic anemia were utilized (Fig. and ). A sharp but transient iall in the percentage of reticulocytes is a convincing demon- stration ol the inhibition of blood 7 I 6 I 5 _^ I colchicine i jr. 4- , xlO^ euk. ^r« SO 45 40 35 30 25 20 15 10 5 1 1 •,\ -•—s ^ I I I I I _ 1 9 DAYS 10 F!g. —Blood changes in the adult rabbit. Colchicine-leukocytosis and sharp fall of the numbers of reticulocytes (immature red-blood cells). The importance of the mitotic disturbances of the erythroblasts is evidenced by the slow return of the reticulocyte number to normal, and by a slight anemia. (Unpublished, after P. Dustin"^) On the other hand, Dixon and Maiden-' disco\ered that in rabbits and dogs an injection of colchicine was followed by a considerable in- crease in the number of circulating white blood cells (Figs. and ). These authors, while reporting this curious effect, mentioned that 12 hours after the injection, tlie bone marrow of rabbits apjK-ars empty of most of its nucleated cells. Fhis is in agreement with observations of bone-marrow aplasia, sometimes fatal, which have since been recorded in the medical literature (cf. Chapter 10). The British authors-^ expressed their conclusions in a rather mis- leading way, to cjuote: "evidence is conclusive that colchicine is a pow- erfid stimulant to the bone-marrow, since it tmns out into the circu- lation all the elements including the erythroblasts, and leaves the. Please note that these images are extracted from scanned page images that m
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