. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 1018 ADVENTUKES IX RADIOISOTOPE RESEARCH Figure 17 demonstrates the result of the first investigations carried out on the permeabiUty of the capillary wall^^^\ It brought out the very great speed at which ions of the plasma interchange with those of the extra vascular space. In the course of 1 minute half of the sodium atoms originally located in the circulation leave the plasma of the rabbit. In the human organism after the lapse of 18 minutes 80 per cent equipartition of the sodium ions. originally present in the plas
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 1018 ADVENTUKES IX RADIOISOTOPE RESEARCH Figure 17 demonstrates the result of the first investigations carried out on the permeabiUty of the capillary wall^^^\ It brought out the very great speed at which ions of the plasma interchange with those of the extra vascular space. In the course of 1 minute half of the sodium atoms originally located in the circulation leave the plasma of the rabbit. In the human organism after the lapse of 18 minutes 80 per cent equipartition of the sodium ions. originally present in the plasma is reached^^"^.. Min YiG. 17. — Rate of extrusion of intravenously injected labelled ions from the circulation of the rabbit, expressed in dilution volume of body water. In the early experiments which lead to the results seen in Fig. 17, blood samples were taken at intervals and their radioactivity compared. The great progress made in the construction of measuring devices makes it possible today to follow the disappearance of radioactive sodium from the circulation by placing a scintillation counter in the precordial region and to measure activity changes within extremely short time intervals. Our knowledge on the pattern of disappearance has also been much increased since the first investigations were carried out in this field. We know now that the curve representing the distribution and disappear- ance of injected radioactive sodium from the plasma is composed of at least 6 components. The first, very rapid component is followed by a second one which was measured by Strajman and his associates^^^^ in men and women of different ages. Their very instructive results are seen in Fig. 18. With increasing age, presumably due to an increasing arterial sclerose, the distribution of the injected sodium ions in the circula- tion takes place at a decreasing Please note that these images are extracted from scanned page images that may have been digitally enhanced for rea
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