Archives of internal medicine . animalswere given no food or acid and only a measured amount of water. In all E. M. ABLER—G. BLAKE 485 the experiments the urine was examined daily and the total quantity, theammonia content, and the titratable bases were determined. The urinewas furthermore examined for albumin or sugar, acetone and blood. Atno time did we find either albumin or sugar, and, as was to have beenexpected in dogs, at no time did acetone appear in the urine even in theseverest, fatal, case. The ammonia determinations were made accordingto the method of Folin.^ ExpEBiMENT 1 (Table 1)
Archives of internal medicine . animalswere given no food or acid and only a measured amount of water. In all E. M. ABLER—G. BLAKE 485 the experiments the urine was examined daily and the total quantity, theammonia content, and the titratable bases were determined. The urinewas furthermore examined for albumin or sugar, acetone and blood. Atno time did we find either albumin or sugar, and, as was to have beenexpected in dogs, at no time did acetone appear in the urine even in theseverest, fatal, case. The ammonia determinations were made accordingto the method of Folin.^ ExpEBiMENT 1 (Table 1).—Feb. 23, 1909. Large male mongrel dog. Con-stant diet of 250 gm. dog biscuit and 600 of water mixed together andmade into thick paste. In addition the dog received water of which he tookvarying amounts as indicated in the table. The acid feeding was begun March 8and continued until the 23d. From March 18 he was given two feedings of acida day. On March 19 diarrhea set in and persisted until the end of the 7bto/Aa • li 25 Zr 23 / 3 5 7 a // a /s Chart 5.—Diagram of ammonia excretion and alkali retention, Experiment 5,Table 5. On ^larch 26 the dog vomited shortly after the acid feeding and continued thisuntil the end of the experiment. Vomitus consisted at first from 10 to 20 mucus mixed with the acid solution. Later small amounts of food appearedin the vomitus. Experiment 2 (Table 2).—March 8, 1909. Small fox terrier bitch. Sameamount of food given and under the same conditions as in Experiment 1. Theacid feeding was begun on March 15 and continued daily until April 9. Theanimal appeared well and was very lively during the entire experiment. OnMarch 21 diarrhea set in and continued until the end of experiment, but thisdid not seem to interfere with the general health. About March 20 it was notedthat she was in heat and the table and the curve show that the amount of alkaliexcreted rose to enormous proportions. Although this entirely vitiated
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