Archives of internal medicine . he blood-pressure and intraspinalpressure in millimeters of mercury; also the pulse-rate and respiratory-rate per minute. The upper continuous line represents the blood-pres-sure; the upper broken line, the pulse-rate; the lower continuous linerepresents the intraspinal pressure; the lower broken line (—.—.) showsthe number of respirations per minute. Group I.—Experiments 5, 9 and 11 (Figs. 2, 3 and 4) were of briefduration. The injections caused death in a very short time from cessa-tion of the respiration and pronounced cardiac inhibition. The respira-tion cea
Archives of internal medicine . he blood-pressure and intraspinalpressure in millimeters of mercury; also the pulse-rate and respiratory-rate per minute. The upper continuous line represents the blood-pres-sure; the upper broken line, the pulse-rate; the lower continuous linerepresents the intraspinal pressure; the lower broken line (—.—.) showsthe number of respirations per minute. Group I.—Experiments 5, 9 and 11 (Figs. 2, 3 and 4) were of briefduration. The injections caused death in a very short time from cessa-tion of the respiration and pronounced cardiac inhibition. The respira-tion ceased from one to three minutes before the heart stopped, and intwo of these experiments death occurred in spite of artificial respiration. Lowering the intraspinal pressure relieved the cardiac inhibition tem-porarily in Experiment 5, but failed to do any good in Experiment 9. IMS 11-20 i<ttf 11=30 IftS mo MS. I MO IISS WO IMS IW m \ioc\ioc\ioc\\50cc\ \socc. I In-Pre5=/S0u^ ISO *(V , ^ r .. ^ • ISO -A AI. 100 SO -0 Doa-,;, Fig. 10 (Exp. IV).—As a type of Group V. The first two injections producedsome cardiac inhibition but subsequent injections of larger amounts had no exceptional results are explained by the escape of the fluid to the extraduralspace as described in the text. The administration of atropin after alarming symptoms had devel-oped (Exps. 9 and 11) caused the cardiac inhibition to disappear butfailed to start the respirations, and the animals soon died. In the experiments of this group comparatively small amounts of fluidwere injected, viz., 10 , 13 and 40 The injecting pressure(from compressed air) was 150 mm. of mercury, plus the column of fluidin the buret. The latter varied from the equivalent of 10 to 40 mm. ofmercury, as previously explained. Serious symptoms developed when the intraspinal pressure had beenincreased to 7 mm., 26 mm. and 66 mm. of mercury in the respectiveexperiments. Fatal results
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