. The actinomycetes. Actinomycetales. DESCRIPTIONS OF ANTIBIOTICS •2\): activity on Voshida sarcoma aiul ascites hepa- toma (12, 15). : Mice tolerate 6 mg per kg suhcutane- ously or intravenously, and 108 mg per kg orally References: 1. Hata, T. et al. Kitasato Arch. Med. 22: 229-242, 19-49. 2. Hata, T. et al. J. Antibiotics (Japan) 3: 313-325, 1950. 3. Kiiroya, M. et al. J. Antibiotics (Japan) 4: 363-366, 1951. 4. Hosoya, S. et al. Japan. J. I^.xptl. Med. 21: 411-417. 1951. 5. , S. et al. Japan. J. I^\i>tl. Med. 22: 313-316, 1952. 6. Hata, T. et al. J. Antil)iotics
. The actinomycetes. Actinomycetales. DESCRIPTIONS OF ANTIBIOTICS •2\): activity on Voshida sarcoma aiul ascites hepa- toma (12, 15). : Mice tolerate 6 mg per kg suhcutane- ously or intravenously, and 108 mg per kg orally References: 1. Hata, T. et al. Kitasato Arch. Med. 22: 229-242, 19-49. 2. Hata, T. et al. J. Antibiotics (Japan) 3: 313-325, 1950. 3. Kiiroya, M. et al. J. Antibiotics (Japan) 4: 363-366, 1951. 4. Hosoya, S. et al. Japan. J. I^.xptl. Med. 21: 411-417. 1951. 5. , S. et al. Japan. J. I^\i>tl. Med. 22: 313-316, 1952. 6. Hata, T. et al. J. Antil)iotics (Japan) 5: 529-534, 1952. 7. Sano, Y. J. Antibiotics (Japan) 5: 535- 538, 1952. 8. Nakase, Y. and Hata. T. J. Antiliiotics (Japan) 5: 542-547, 1952. 9. Hata, T. et al. Kitasato Arch, l-^xptl. Med. 24: 447-457, 1952. 10. Sano, H. Kitasato Arch. Exptl. Med. 24: 459-467, 1952. 11. Nakase, Y. and Hata, T. Kitasato Arch. Exptl. Med. 24: 469-480, 1952. 12. Hosoya, S. et al. J. Antil)iotics (Japan) 6.\: 42, 1953. 13. Osato, T. et al. J. Antil)iotics (Japan) 6A: 52-56, 1953. 14. Kamada, T. J. Antibiotics (Jajnin) 6A: 172-181, 1953. 15. Koga, F. J. Antibiotics (Japan) TV: 176, 1954. 16. Govorcin, B. Tehnicki Pregled Zagreb 8: 43 52, 1956. .^l;iiiii«)si«l«>slfeptoniyciii Produced hi/: Streptoitu/ces griseiis (1). This organism also produces , strei)tocin, and streptomycin (6). Si/nont/iii: Streptomycin B (1). Remarks: Mannosidostreptomycin is cleaved to streptomycin by the enzyme mannosidostrejito- mycinase (5). Method of : I'^xtracted from bi-(jtli along with streptomycin. Separated by chroma- tography on acid washed alumina with 50 per cent methanol as solvent and developer. The more firmly absorbed, less active fractions con- tain mannosidostreptomycin. Crystallized as the reineckate and converted to the hydrochloride (1, 2). See alsf) II and \'I under streptomycin. Chemical and physical properties: Trihi/dro- chloride: White amorphous powder; 17
Size: 1815px × 1376px
Photo credit: © Library Book Collection / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookcoll, bookpublisherbaltimorewilliamswilkins
