. The effects of inanition and malnutrition upon growth and structure . Pig. 55.âFrom a photograph of a portion of a section through the costochondral joint of a normal guinea pig; body weight 236 g. C, costal cartilage; Z, zone of enchondral ossification (bony and calcified cartilaginous trabeculae, and invading marrow); M, costal marrow; D, bone of costal diaphysis; P, costal periosteum and adjacent intercostal muscle. Zenker fixation; hematoxylin-eosin stain. X40. (Preparation by Everett Rowles.) reviewed by Vincent ('04), Lesage I'n), Schmidt ('21) and especially by Hess ('20). Hojer's ('2
. The effects of inanition and malnutrition upon growth and structure . Pig. 55.âFrom a photograph of a portion of a section through the costochondral joint of a normal guinea pig; body weight 236 g. C, costal cartilage; Z, zone of enchondral ossification (bony and calcified cartilaginous trabeculae, and invading marrow); M, costal marrow; D, bone of costal diaphysis; P, costal periosteum and adjacent intercostal muscle. Zenker fixation; hematoxylin-eosin stain. X40. (Preparation by Everett Rowles.) reviewed by Vincent ('04), Lesage I'n), Schmidt ('21) and especially by Hess ('20). Hojer's ('24) recent monograph is excellent. The gross skeletal lesions include osteoporosis, with fragility and thinning of the cortex in the shaft of the long bones, and frequent occurrence of fractures in severe cases. Enlargement of the costochondral joints occurs, and has frequently been mistaken for rickets (cf. Hess '20; Hess and Unger '20). The general hemorrhagic condition in scurvy is manifested in the skeleton by frequent sub- periosteal and marrow hemorrhages. The bone marrow undergoes changes, becoming more fibrous or gelatinous in appearance, especially at the ends of the long bones. Hemorrhages and fractures with enlarged calluses are most frequent in pre-adult cases at the junction of the diaphysis with the epiphyseal cartilage. The microscopic changes in the skeleton have been studied in detail, espe- cially during infantile scurvy. Although there is much variation in different
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Keywords: ., bookcentury1900, bookdecade1920, bookpublis, booksubjectnutrition
