. A study of the causes underlying the origin of human monsters : third contribution to the study of the pathology of human embryos . neous tissue are thick-ened, being composed of one mass of round cells. The form of the brain and its structure are pretty well pre-served, while the tissues of the liver and intestine are necroticand macerated. It appears as if the growth of the embryohad been retarded with a continued growth and change inthe connective tissues. Then, after its death, the embryo wasretained in the uterus for some time. At points all overthe body there are thickened spots in the


. A study of the causes underlying the origin of human monsters : third contribution to the study of the pathology of human embryos . neous tissue are thick-ened, being composed of one mass of round cells. The form of the brain and its structure are pretty well pre-served, while the tissues of the liver and intestine are necroticand macerated. It appears as if the growth of the embryohad been retarded with a continued growth and change inthe connective tissues. Then, after its death, the embryo wasretained in the uterus for some time. At points all overthe body there are thickened spots in the skin which are epithelial in nature, but they are located below the 3o8 MALL. [Vol. XIX. No. 320. Ovum, 70 x 50 x 40 mm.; embryo, 18 mm. Dr. Gibbs, Baltimore. The chorion is fleshy and thick, with irregular spots of villicovering its surface. Some of the villi are fibrous and othersare swollen; all are deficient in syncytium. The decidua isnot typical, being well filled with fibrin, with occasional massesof leucocytes. Within, the entire chorion is lined by theamnion, which contains no magma. The umbilical cord is. Fig. 320a.—Whole ovum. Natural size. thin at its attachment to the chorion, but in its middle it isswollen, which, upon microscopic examination, proved to bea vesicle filled with a hyaline stringy mass tinged with car-mine. Otherwise the cord is fibrous, and in its center areseen the remnants of its blood-vessels. They are practicallyobliterated. The tissues of the embryo are pretty well dissociated, thecord and brain being nearly solid, with occasional irregularspaces representing the central canal. The outlines of the No. i.] ORIGIN OF HUMAN MONSTERS. 309 Fig. 320b.—Embryo within the ovum. X 2 times. 3io MALL. [Vol. XIX.


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