Manual of pathological anatomy . the red, have been observed. Theblood, in fatal cases, is often found imperfectly coagulated—some-times grumous, of a dirty brown colour. The coagula, wheredecolorized, have not the aspect of healthy fibrine, but are of amore opaque dull yellow, and, when broken up, resemble thickcreamy pus. They contain in this part very numerous white cor-puscles, to which the peculiar aspect is no doubt due. The redcorpuscles are invariably diminished; the solids of the serum littlealtered; but the specific gravity of the blood shows a constant dimi-nution (from 1055 to 1040
Manual of pathological anatomy . the red, have been observed. Theblood, in fatal cases, is often found imperfectly coagulated—some-times grumous, of a dirty brown colour. The coagula, wheredecolorized, have not the aspect of healthy fibrine, but are of amore opaque dull yellow, and, when broken up, resemble thickcreamy pus. They contain in this part very numerous white cor-puscles, to which the peculiar aspect is no doubt due. The redcorpuscles are invariably diminished; the solids of the serum littlealtered; but the specific gravity of the blood shows a constant dimi-nution (from 1055 to 1040 or 1035). The iron is also deficient fromthe paucity of red corpuscles. In some cases the blood has had an acidreaction, and has contained xanthin and hypoxanthin (bodies alsoobtained from the spleen), together with gelatin and some othernitrogenous substances of simpler constitution, and lactic acid. Morbid Anatomy.—Morbid changes are chiefly observed, in thefirst place, in the spleen and the lymphatic glands; secondly, in. 74 LETJCOCYTHJEMIA OR LEUCH^MIA. various organs whicli are regarded as resembling lymph-glands instructure, viz., the tonsils, and other follicular structures of theintestinal tract, and the red medullary tissue of bones; andfinally, in very different organs, as the liver, kidneys, lungs, & of these morbid changes are regarded as primary^ beingthought to be the cause of the state of the blood; others are calledsecondaryy being regarded as its consequences. Primary Morbid Changes.—The researches of numerous patho-logists, more especially of Yirchow,* Bennet,t Neumann,JHosier, § and Behier, have shown the very close connection ofthis disease with changes in certain organs, which are believed totake part in the formation of the colourless corpuscles of the blood,viz., the spleen, the lymphatic glands, and the red medulla ofbones, as well as, in an inferior degree, other lymphatic structures,such as the follicles of the digestive tract. The supera
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