Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . atdescribed. By the changes already noted, the capillary blood-supply iscut oft from the center, favoring the occurrence of necrotic and degenera-tive processes brought about by the specific action of the bacillus, or, moreproperly, of the bacillary products. Coagulation necrosis terminates insolidification of any Hquid exudate the product of which, with the deadcells, proceeds to caseation. In the beginning of this process granular andfatty changes occur in the cell protoplasm, the c
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . atdescribed. By the changes already noted, the capillary blood-supply iscut oft from the center, favoring the occurrence of necrotic and degenera-tive processes brought about by the specific action of the bacillus, or, moreproperly, of the bacillary products. Coagulation necrosis terminates insolidification of any Hquid exudate the product of which, with the deadcells, proceeds to caseation. In the beginning of this process granular andfatty changes occur in the cell protoplasm, the cell outlines become in-distinct or disappear, and the nuclei shrivel and disintegrate; the nuclearfragments often retain their affinity for basic dyes long after the struc-turally perfect cell has disappeared. The caseous area produced by theforegoing changes may follow the peripheral extension of the processuntil two or more tubercles join by confluence into the formationof a single mass. Caseation may be accompanied by liquefaction,coagulation, or hyaline necrosis; eventually, the mass is converted into. Fig. 83.—Diagram of the Structure of a Tuber-cle; A Purely Theoretic Idea, RarelyDemonstrated.—(Gottld.) n.\( IKKIA AS CVrSKS ol- DISEASK. i5» a yellowish nodule of structureless detritus,the so-called yellow tubercle;prior to the stage of softening the mass was referred to as a gray tubercle ;where a number of these run together, tlie collection shows a decidedtendency to evacuate itself hy discharge through the most feasibleroute, leaving behind a cavity or ulcer. If not in all, certainly in alarge percentage of the cases, dissolution of the tubercle is broughtabout through a secondary infection by the organisms of tuberculous ulcer and abscess are more commonly, particularlvin the respiratory organs, hastened to their full development bv theadded pyogenic invasion. This terminates the process of softening, andis an unfavoral)le ending of the tuberculou
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