. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 640 ADVENTURES IX RADIOISOTOPE RESEARCH THE CAPACITY OF PLASMA PROTEINS FOR COMBINING WITH IRON The interpretation of the manifold cHnical experience that a part of the injected iron disappears very rapidly, as observed earlier by Waldenstrom and others, was made considerably easier by the dis- covery by HoLMBERG and Laurell^^^ that the physiological iron of the plasma is attached to a protein fraction in the transferrin. In recent Gosamt — Eiweip — 6,35 gm % Albumin oc, r 41,9 % 9,3 " 13,5 " 14-,2 n 21,1 ? 10
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 640 ADVENTURES IX RADIOISOTOPE RESEARCH THE CAPACITY OF PLASMA PROTEINS FOR COMBINING WITH IRON The interpretation of the manifold cHnical experience that a part of the injected iron disappears very rapidly, as observed earlier by Waldenstrom and others, was made considerably easier by the dis- covery by HoLMBERG and Laurell^^^ that the physiological iron of the plasma is attached to a protein fraction in the transferrin. In recent Gosamt — Eiweip — 6,35 gm % Albumin oc, r 41,9 % 9,3 " 13,5 " 14-,2 n 21,1 ? 100,0 % Fig. 1. Localization of the binding of radioactive iron to the /?j globuhn of plasma. Gesamt-Eiweiss = total protein. Albumin = albumen. years it has been possible to confirm this result by electrophoretic investigations. For instance, it is evident in Fig. 1, which is taken from the paper of Jasinski and Wuhrmann.^^b) that all the labelled plasma iron detected autoradiographically is situated in the same position as the i^i globulin fraction. The main portion of the transferrin of the /S^ globulin is present in the IV : 7 fraction of the plasma. If more ferrous sulphate is added to the plasma than can be bound by the amount of transferrin present, then the excess reacts, in contrast to the iron in transferrin, with dipyridyl. The transferrin of the plasma in a healthy person can combine with about 315 /^gm % of iron. Laurell^^^ ascertained the combining capacity of the plasma for iron, both in physiological and pathological conditions in numerous cases, in his comprehensive studies in which he also established the diagnostic importance of this quantity. A plasma iron content of 150 figm % may, however, be taken as normal. This applies when it is postulated that the combining capacity of plasma for iron amounts to about SOO^agm %. When the combining capacity for iron is decreased owing to the abnormal synthesis of protein, as in pernicious anaemia, a plasma iron
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