. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. SPONTANEOUS NEOPLASMS IN MICE 20.; Fibrosarcoma.—Among the more common malignant tumors in the subcutaneous region, the fibrosarcoma is the tumor most often observed. However, no stock of mice shows a frequency of subcutaneous tumors which would enable one to call it a high tumor stock in that respect. It is unusual to find a stock showing over 15 per cent of the mice with tumors other than mammary carcinoma in this region. Many fines of mice show considerably less. Fibrosarcoma originates from the
. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. SPONTANEOUS NEOPLASMS IN MICE 20.; Fibrosarcoma.—Among the more common malignant tumors in the subcutaneous region, the fibrosarcoma is the tumor most often observed. However, no stock of mice shows a frequency of subcutaneous tumors which would enable one to call it a high tumor stock in that respect. It is unusual to find a stock showing over 15 per cent of the mice with tumors other than mammary carcinoma in this region. Many fines of mice show considerably less. Fibrosarcoma originates from the fibrous connective tissue cells. The basic architecture is the same whether it develops in the mammary line and. Fig. 112. -Fibrosarcoma of the subcutaneous connective tissue showing the typical interlacing pattern of the spindle cells (X200). its branches or in any other subcutaneous focus. Grossly, the tumor is a compact mass with a smooth, rounded, white surface. The cut surface is uniform, bulging and varies from soft to firm. Microscopically it shows closely packed spindle-shaped tumor cells (Fig. 112). Their architecture presents a picture of solid masses of cells alternating with large and small whorls and interlacing bands of fibrous connective tissue tumor cells. The tumor cells exceed the stroma and the latter is difficult to identify, but appears to be represented by inconspicuous stromal connective tissue cells surrounding the individual tumor cells. Fibrosarcoma tumor cells often appear slightly separated, as though shrunken away from the intercellular stroma. Small, endothelial lined thin-walled blood vessels are abundant. Invaded tissues such as striated muscle, nerves, large blood vessels and mam- mary glands may be seen, for no capsule is present and infiltration Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectl
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Keywords: ., boo, bookcentury1900, bookcollectionbiodiversity, booksubjectmice
