. The Biochemical journal, 1906. Biochemistry. 332 BIO-CHEMICAL JOURNAL This effect occurs equally before and after section of both vagi as well as after the administration of nicotine and is probably due, as suggested by Cole, to a direct action on the respiratory centre. Whether the effect is primarily, or indeed chiefly upon the diaphragm as stated by Cole we cannot be certain. In some instances the animal recovers after respiration has been in abeyance for one minute or even for a longer period, the respiration beginning with very small movements and gradually increasing in extent. (See Fi
. The Biochemical journal, 1906. Biochemistry. 332 BIO-CHEMICAL JOURNAL This effect occurs equally before and after section of both vagi as well as after the administration of nicotine and is probably due, as suggested by Cole, to a direct action on the respiratory centre. Whether the effect is primarily, or indeed chiefly upon the diaphragm as stated by Cole we cannot be certain. In some instances the animal recovers after respiration has been in abeyance for one minute or even for a longer period, the respiration beginning with very small movements and gradually increasing in extent. (See Fig. 2.) As a rule the recommencing respiratory move- ments, although shallow, are very frequent. (See Figs. 3, 5, and 7.). Fig. 3. Hind limb respiration. Carotid blood pressure. Dog, 10 K, — nicotine—both vagi cut. Ethyl chloride. Shows sudden stoppage of respiration with recovery. No steps taken to aid recovery. Ether-morphia-curari-nicotine. Both vagi cut. With a fatal dose the respiration, after being stopped for two or more minutes, will usually become re-established for a few seconds before death ; stopping finally at the same time as, or a few seconds before the heart. (See Fig. 4.). Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Biochemical Society (Great Britain); University of Liverpool. Biochemical Dept. London [etc. ] Cambridge University Press
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