. The Biochemistry of B vitamins. Vitamins; Vitamin B complex. Chapter VIMD THE VITAMIN B6 GROUP Although a dermatitis, termed acrodynia, which is characteristic of vitamin B6 deficiency, was observed as early as 1926 in rats fed a deficient diet,1 it was not until 1934 that Gyorgy 2 established that the "rat pel- lagra preventitive" factor was a new B vitamin (vitamin B6); it was subsequently isolated in crystalline form independently in five different However, in 1932 Ohdake 8 isolated from rice polishings a compound apparently identical with vitamin B6, but did no
. The Biochemistry of B vitamins. Vitamins; Vitamin B complex. Chapter VIMD THE VITAMIN B6 GROUP Although a dermatitis, termed acrodynia, which is characteristic of vitamin B6 deficiency, was observed as early as 1926 in rats fed a deficient diet,1 it was not until 1934 that Gyorgy 2 established that the "rat pel- lagra preventitive" factor was a new B vitamin (vitamin B6); it was subsequently isolated in crystalline form independently in five different However, in 1932 Ohdake 8 isolated from rice polishings a compound apparently identical with vitamin B6, but did not recognize it as a vitamin. The structure of vitamin B6 indicated below was first elucidated by Kuhn and co-workers 9<10,11 and subsequently was confirmed by inde- pendent work of other CH2OH CH2OH. vitamin B6 (pyridoxine, adermin) The synthesis of vitamin B6 was accomplished shortly afterward by Harris and Folkers,16 by Kuhn and co-workers,17 and by Morii and Specificity During the proof of structure and synthesis of vitamin B6, a number of structurally related compounds were prepared and tested for vitamin B6 activity. The activities of these compounds in replacing vitamin B6 for various organisms are indicated in Table 35. Although many of the organisms respond similarly to the various ana- logues of pyridoxine, there are a few instances which contrast markedly. Thus, 2-ethyl-3-hydroxy-4,5-bis(hydroxymethyl) pyridine, which is as active as pyridoxine for stimulation of growth of excised tomato roots, in- hibits the utilization of pyridoxine by Ceratostomella ulmi; but 2-methyl- 3-hydroxy-4-ethoxymethyl-5-hydroxymethylpyridine, which is 1 to 5 per cent as active as pyridoxine for Ceratostomella ulmi, is quite injurious. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Willia
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