. The thyroid gland in health and disease. new acini are formed in the intervesicular tissue(figs. 12, 13). 7. In artificially-produced goitre in the rat granular massesof intensely staining basophil granules, lying in the intervesiculartissue, are conspicuous objects. They resemble masses of cocci,but are probably the granules of mast cells. 8. There is a greatly increased discharge into the lymphspaces and acini of thin gelatinous secretion from the heightened 64 PATHOLOGY epithelium ; it is very pale-staining. The edges of the epithelialcells often merge with the secretion in the acini, or
. The thyroid gland in health and disease. new acini are formed in the intervesicular tissue(figs. 12, 13). 7. In artificially-produced goitre in the rat granular massesof intensely staining basophil granules, lying in the intervesiculartissue, are conspicuous objects. They resemble masses of cocci,but are probably the granules of mast cells. 8. There is a greatly increased discharge into the lymphspaces and acini of thin gelatinous secretion from the heightened 64 PATHOLOGY epithelium ; it is very pale-staining. The edges of the epithelialcells often merge with the secretion in the acini, or break off toform part of it. The acini contain a debris of broken-down cellsinto which leucocytes and red blood corpuscles wander (fig, 10). 9. Pari passu with this multiplication of cells and new vesicleformation, a greater or lesser increase of the fibrous stroma(fig. 16), and an accumulation of lymphoid cells occur; thelatter may form a conspicuous feature of the gland in cases ofGraves Disease, but is not so evident in simple .j** * ?«?? • *. Fig. 12.—Section of goitrous thyroid of rat. Due to feeding on intestinalanaerobes. Note disappearance of colloid; small size of vesicles, many new ; highvesicular epithelium, vacuolation of protoplasm around nuclei ; great increaseof intervesicular parenchyma. X 166. The process is largely compensatory in character, but to it isadded a chronic inflammatory element due to the action oftoxic agents on the gland. It may vary in its acuteness or in itschronicity, as well as in degree. The whole organ may be involvedin it, and is so as a rule, but occasionally different parts of thegland maybe affected in different degrees. It mayor may notgive rise to enlargement of the gland depending on the virulenceof the toxin, the continuance of its action, the state of nutrition EXPERIMENTALLY-PRODUCED GOITRE 65 ;w Fig. 13.—Section of goitrous thyroid from a rat fed on ciiltures fromgoitrous faeces. Note absorption of colloid, great
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