. The American journal of roentgenology, radium therapy and nuclear medicine . curves are shown In in a lethal radiation dose for each type of Figure i. The full skin dose, that is, the carcinoma cells. 100 per cent erythema skin dose, is attained 786 Act ion ol Measured Radiation Doses on Carcinomata of the Uterine Cer\Ix at isodose 60 with 1600 mg. element hours,(mg. el. hrs.,) at isodose 40, with 2400mg. el. hrs.; at isodose 30, with3200 ; at isodose 20, with 4800 mg. el. hrs.;at isodose 10, with 9600 mg. el. hrs. Themedian transverse diameter of isodose 60 isabout 3 cm., the long
. The American journal of roentgenology, radium therapy and nuclear medicine . curves are shown In in a lethal radiation dose for each type of Figure i. The full skin dose, that is, the carcinoma cells. 100 per cent erythema skin dose, is attained 786 Act ion ol Measured Radiation Doses on Carcinomata of the Uterine Cer\Ix at isodose 60 with 1600 mg. element hours,(mg. el. hrs.,) at isodose 40, with 2400mg. el. hrs.; at isodose 30, with3200 ; at isodose 20, with 4800 mg. el. hrs.;at isodose 10, with 9600 mg. el. hrs. Themedian transverse diameter of isodose 60 isabout 3 cm., the longitudinal axis cm.;at isodose 40, and cm. respectively;at isodose 20, 7 and 8 cm.; at isodose 10, apply is with 130 per cent E. S. D. 4200mg. el. hrs., and with 150 per cent E. S. mg. el. hrs. Assuming that a carcin-oma had a radio-sensibility of 100 per centand occupied an elliptical area of a mediantransverse diameter of 7 cm. and a longi-tuduial axis of 8 cm., the carcinoma doseot 4800 mg. el. hrs. would be if we use radium alone we can. irf^-^ Fig. 7. High-power magnificition of an area of Figure 6 to show the degeneration of the nuclei and protoplasm of the cancer cells. and cm. The object of radiationtherapy must be to kill the carcinomawithout causing irreparable injury tonormal tissues and organs lying within thepath of the radiation field. The posteriorbladder wall is about cm., and theanterior rectal wall about to 3 from the cer\ ical canal. The per-missible maximal radiation dose whichthe rectal and vesical mucosae will endurewithout permanent injury is about 130 to150 per cent of the erythema skin they lie at about isodose 30 the highestpermissible gamma ray dose that we may benefit only a small number of cer\icalcarcinomata. Should the radio-sensibilityof the carcinoma be less than 100 per centand the E. S. D. be i^o to 1-5 per cent,then the prognosis would be less radiation energy
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