. The endocrine organs; an introduction to the study of internal secretion . uretic action (upon the cells) fails to be produced whilst the vasculareffects are pronounced, or vice versa. But even if this were valid for thekidney, there are strong reasons for the belief that the posterior lobe ofthe pituitary yields more than one autacoid. For there is distinct evidencethat a specific hormone affects the secretion of milk ; quite possibly theeffect upon the uterus is due to another; while there is very little doubtthat the fall of blood-pressure produced by a second dose of pituitaryextract is
. The endocrine organs; an introduction to the study of internal secretion . uretic action (upon the cells) fails to be produced whilst the vasculareffects are pronounced, or vice versa. But even if this were valid for thekidney, there are strong reasons for the belief that the posterior lobe ofthe pituitary yields more than one autacoid. For there is distinct evidencethat a specific hormone affects the secretion of milk ; quite possibly theeffect upon the uterus is due to another; while there is very little doubtthat the fall of blood-pressure produced by a second dose of pituitaryextract is due to a chalonic agent entirely different from the hormonecausing the initial rise. Bayer and Peter have also produced evidencethat there are two autacoids which act upon intestinal muscle, one produc-ino; inhibition and the other contraction. o Important observations bearing upon this question have been made 7 98 The Endocrine Organs by Herring, who finds well-marked differences of effect according asextracts are prepared from pars intermedia or pars Thus pars. FIG. 68.—Effects on blood-pressure and kidney volume of injecting 3 of a 2 per cent, extractof pars intermedia of fresh ox pituitary into the jugular vein of a cat. (Herring.) a, blood-pressure ; l>, kidney volume ; c, urine drops ; d, signal; e, time in ten-second intervals. a WWWWiAM/, f
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