. The Biochemical journal, 1918. Biochemistry. ANTrSCORRTTTIC F.\(T()|{ IX JIK'H 201 Expt. 2. Our next aim was to ascertain approximately what proportion of the antiscorbutic content of lemon juice remains in the residue after the re- moval of the acids. It has previously been pointed out by us in another communication [1918] that with our prjsent technique it is impossible to carry out quantitative determinations of the antiscorbutic content of a solution with any great precision. It is nevertheless possible to ascertain roughly the relative antiscorbutic potency of two solutions l)y a
. The Biochemical journal, 1918. Biochemistry. ANTrSCORRTTTIC F.\(T()|{ IX JIK'H 201 Expt. 2. Our next aim was to ascertain approximately what proportion of the antiscorbutic content of lemon juice remains in the residue after the re- moval of the acids. It has previously been pointed out by us in another communication [1918] that with our prjsent technique it is impossible to carry out quantitative determinations of the antiscorbutic content of a solution with any great precision. It is nevertheless possible to ascertain roughly the relative antiscorbutic potency of two solutions l)y administering equal quantities of the solutions to guinea pigs of approximately the same weight kept on a scorbutic diet and watching the chnical developments. We have adopted this procedure in this experiment. Doses of 0-5 cc. 1 cc. and l-H cc. 550. 60 70 80 90 Fig. 1 each of treated and untreated lemon juice respectively were given to six guinea pigs. Animals Nos. 263, 267 and 268 received 0-5 cc, 1 cc. and 15 cc. of untreated lemon juice respectively, while Nos. 266, 264 and 265 received 0-5 cc, 1 cc. and 1*5 cc. of treated lemon juice. Fig. 2 represents their weight curves. Guinea pigs Nos. 263 and 260 receiving 0-5 cc. of untreated and treated lemon juice respectively died of scurvy within about a month, showing that 0-5 cc. eithei' of treated or untreated lemon juice is insufficient to prevent guinea pigs from succumbing to scurvy. No marked differentinl clinical features could be observed in these animals. The behaviour of Nos. 2<)1 and 267 which received a dose of 1 cc. was also very similar. They were both chloroformed 17—2. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Biochemical Society (Great Britain); University of Liverpool. Biochemical Dept. London [etc. ] Cambridge University Press
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