. The Biochemistry of B vitamins. Vitamins; Vitamin B complex. 680 THE BIOCHEMISTRY OF B VITAMINS Table 40. Competitive Inhibitors of Flavin-Adenine-Dinucleotide for D-Amino Acid Oxidase62 . Quinine Equivalent* At 37° C At 30° C Auramine 7 Atebrin 2 Novalauramine 2 Quinine 1 1 Quinine methochloride 1 1 6-Methoxyquinoline 1 1 Plasmochin 1 7-Chloro-4-(4-diethylamino-l-methylbutyl- amino)-2-methylquinoline 1 7-Chloro-4- (4-diethylamino- 1-methylbutyl- amino)-3-methylquinoline 7-Chloro-4- (4-diethylamino- 1-methylbutyl- amino)quinoline a-(Diamylaminomethyl)-l,2,3,4-tetrahydro-
. The Biochemistry of B vitamins. Vitamins; Vitamin B complex. 680 THE BIOCHEMISTRY OF B VITAMINS Table 40. Competitive Inhibitors of Flavin-Adenine-Dinucleotide for D-Amino Acid Oxidase62 . Quinine Equivalent* At 37° C At 30° C Auramine 7 Atebrin 2 Novalauramine 2 Quinine 1 1 Quinine methochloride 1 1 6-Methoxyquinoline 1 1 Plasmochin 1 7-Chloro-4-(4-diethylamino-l-methylbutyl- amino)-2-methylquinoline 1 7-Chloro-4- (4-diethylamino- 1-methylbutyl- amino)-3-methylquinoline 7-Chloro-4- (4-diethylamino- 1-methylbutyl- amino)quinoline a-(Diamylaminomethyl)-l,2,3,4-tetrahydro- 9-phenanthrenemethanol Sulfathiazole Sulfapyridine Sulfadiazine Sulfanilamide Benzenesulfonamide N- (4-Diethylamino-1 -methylbutyl)-/3- (p-dimethylaminophenyl)alanine Aniline Pyridine 0L-a-(p-Dimethylaminophenyl)glycine * The ratio of concentrations of quinine and inhibitor required to give the same amount of inhibition at any concentration of flavin-adenine-dinueleotide. active as quinine. The sulfonamides are considerably less effective. The dissociation of the coenzyme from D-amino acid oxidase does not occur readily at 30° C, but dissociation is readily detectable at 37° C. At the latter temperature, the inhibitions resulting from quinine appear to be reversible and competitive with the coenzyme. The dissociation constants for two different enzyme preparations are X 10 7 and X 10 7 for the enzyme complex and X 1(H and X 1(H for the quinine-apoenzyme complex. With atebrin, two types of inhibition appear to exist. One is (CH3)2—N+=< \=C—<f \-N(CH3)2 ci:7X=/ I \=J NH2 auramine C2H5 NH—CH—CH2—CH,—CH2—N I \ CH3 C2H6 plasmochin. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Williams, Roger J
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