Brooklyn medical journal. . ° to 1050 F. Very minute portions of bacilli of pure culture in-oculated into the subcutaneous tissue, into the pleural or peritonealcavity, into the anterior chamber of the eye, directly into the bloodstream, and otherwise, have caused artificial tuberculosis withinthe period of three or more weeks; thus, apparently proving that 338 LOUIS F. CRIADO, these microscopic vegetable organisms must be regarded as thespecific cause of tuberculosis. The natural conditions essential forthe development of the bacilli are alone to be found in the animalbody under certain
Brooklyn medical journal. . ° to 1050 F. Very minute portions of bacilli of pure culture in-oculated into the subcutaneous tissue, into the pleural or peritonealcavity, into the anterior chamber of the eye, directly into the bloodstream, and otherwise, have caused artificial tuberculosis withinthe period of three or more weeks; thus, apparently proving that 338 LOUIS F. CRIADO, these microscopic vegetable organisms must be regarded as thespecific cause of tuberculosis. The natural conditions essential forthe development of the bacilli are alone to be found in the animalbody under certain conditions; but withal, the fact most worthy ofconsideration is that these minute organisms have a very tenaciousvitality, capable of withstanding the chemical action of most acids,and of preserving their virulence and necessary requisites for de-velopment for many weeks in decomposing sputum, and for monthsin the dry state. The infective power of tuberculous matter is notdestroyed by desiccation, freezing, or To burden this paper unnecessarily with the symptomatologyand diagnosis of pulmonary tuberculosis would certainly prove animposition on my part; but we must at least refer to some of themost important factors serving to establish, not only the existence ornon-existence of this much dreaded disease, but likewise, the indis-pensable clinical necessity of the microscope. i. It is not an exceptional rule, but a fact, that skilled physi-cians are oftentimes confronted with cases in which the diagnosisby means of the most careful physical examination proves futile;thus, for instance, in the so-called first stage of pulmonary tubercu-losis, or in disseminated pulmonary tuberculosis, where we have to SOME REMARKS ON PULMONARY TUBERCULOSIS. 339 contend with numerous peribronchial nodules disseminated overmost of the entire lung, and still a good deal of normal tissueexists, physical signsâpercussion and auscultationâwill not revealthe true condition of the organs
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