CRISPR-Cas13 gene editing complex, molecular structure. The CRISPR-Cas13 protein is used in genome engineering to cut DNA (deoxyribonucleic acid). It

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CRISPR-Cas13 gene editing complex, molecular structure. The CRISPR-Cas13 protein is used in genome engineering to cut DNA (deoxyribonucleic acid). It uses a guide RNA (ribonucleic acid) sequence (red) to cut DNA at a complementary cleavage site. It is a type VI-D CRISPR-Cas effector (an RNA-guided ribonuclease) that has been re-purposed to edit RNA in a programmable manner. The coding sequence for Cas13d is small enough to fit within the packaging limits of adeno-associated viruses (AAV) for in-vivo delivery.

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Photo credit: © RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY / Alamy / Afripics
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