. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. 216 P. P. Slonimski and H. de Robichon-Szulmajster Table II Comparison of growth and mutation of control and INDUCED cultures No indepen- dent cultures No colonies counted Fre- quency of mutants (%) No cell genera- tions Mutation rate* ( X 10-3) minimum maximum Control 38 ca. 16000 1-2 2-72 1 2 + Euflavine Ito2xl0-6M 68 ca. 30000 67-8 2-52 720 7i0 Data from 12 independent experiments pooled together. * The mutation rate is defined here as the probability of a bud tal
. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. 216 P. P. Slonimski and H. de Robichon-Szulmajster Table II Comparison of growth and mutation of control and INDUCED cultures No indepen- dent cultures No colonies counted Fre- quency of mutants (%) No cell genera- tions Mutation rate* ( X 10-3) minimum maximum Control 38 ca. 16000 1-2 2-72 1 2 + Euflavine Ito2xl0-6M 68 ca. 30000 67-8 2-52 720 7i0 Data from 12 independent experiments pooled together. * The mutation rate is defined here as the probability of a bud talien at random giving rise to a mutant clone (of. Marcovlch, 1951).. 15 X 10 Fig. 2. Frequency of respiration-deficient mutants versus euflavine concentration. Other conditions as in Table Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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