. Journal of radiology . kidney. Male 30 wasproved heterozygous to tumor. This isa case then of mating a tumorous in-dividual (recessive) with a heterozy-gote. In accordance with the Men-delian expectation from such a cross,tumor comes out in the first hybrid gen-eration, namely female 883 with anadenoma of the liver. In the first filial generation, this fe-male 883 with an adenoma of the liver,was hybridized with male 842, whodied of uncertain causes, but who wasproved heterozygous to tumor. Theirson, male 1101 dying from acutenephritis, was heterozygous to livertumor. He was hybridized with
. Journal of radiology . kidney. Male 30 wasproved heterozygous to tumor. This isa case then of mating a tumorous in-dividual (recessive) with a heterozy-gote. In accordance with the Men-delian expectation from such a cross,tumor comes out in the first hybrid gen-eration, namely female 883 with anadenoma of the liver. In the first filial generation, this fe-male 883 with an adenoma of the liver,was hybridized with male 842, whodied of uncertain causes, but who wasproved heterozygous to tumor. Theirson, male 1101 dying from acutenephritis, was heterozygous to livertumor. He was hybridized with female441 (entirely unrelated) who was alsoheterozygous to tumor. Their son, male3024, was hybridized with female3920, who came of a liver tumor an-cestry and who herself had an adenomaof the liver. Note the outcropping ofliver tumor in the second hybrid genera-tion, female 5305 with a sarcoma ofthe liver. Note here how there segre-gated out on the one hand the unitcharacter sarcoma introduced by fe- PART of STRAIN 392-. male 3, five generations back, and onthe other hand the specificity of livertissue type locating tumors in the liver,which also was originally introduced byfemale 3, transmitted through and re-inforced by female 883 and female3920. Note how in this generationthe unit character sarcoma got intocombination with liver tissue of a typeto yield to neoplastic growth (anotherunit character), so that we have infemale 5305 a sarcoma of the liver. This female 5305 was hybridizedwith male 5215, who died of chronicnephritis. Through three succeedinggenerations, by the right selective mat-ings, all occurrence of neoplasm washeld off. But the certainty of its trans-mission by heredity is indisputably dem-onstrated, for, by the use of analyzedindividuals, two mice heterozygous toliver tumor were selected in the thirdfilial generation, namely female 9847,who died of chronic nephritis, and male8852, who died of a lung abscess, sothat liver tumor appeared in the nextgeneration.
Size: 1376px × 1816px
Photo credit: © Reading Room 2020 / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookauthoramerican, bookcentury1900, bookdecade1920, bookyear1922
