. A study of the causes underlying the origin of human monsters : third contribution to the study of the pathology of human embryos . Fig. 21a.—Ovum covered with long irregular villi. Slightly enlarged. From the external appearance, the ovum is apparentlynormal, with well-developed villi branching a number oftimes. Upon opening the specimen it was found that theccelom is filled with a small quantity of magma reticule,within which is embedded a very large transparent Fig. 21b.—Interior of chorion, showing magma and vesicle. X 5 times. This, with its attachment to the chorion, was remo


. A study of the causes underlying the origin of human monsters : third contribution to the study of the pathology of human embryos . Fig. 21a.—Ovum covered with long irregular villi. Slightly enlarged. From the external appearance, the ovum is apparentlynormal, with well-developed villi branching a number oftimes. Upon opening the specimen it was found that theccelom is filled with a small quantity of magma reticule,within which is embedded a very large transparent Fig. 21b.—Interior of chorion, showing magma and vesicle. X 5 times. This, with its attachment to the chorion, was removed andcut into serial sections 20 microns thick. The main vesicle is brought in contact with the chorion bymeans of a small secondary vesicle; both are inclosed with alayer of mesoderm within wrhich are numerous blood islands. 156 MALL. [Vol. XIX. The smaller vesicle is lined with a layer of large spindle-shaped cells. Migrating cells are within the cavities of bothvesicles, and are also scattered throughout the surrounding-magma. There are no blood-vessels in the chorion. The syncytiallayer is diminished, but is well formed upon the tips of thevilli. Here it often accumulates in layers, forming peculiarstrata.


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