The Journal of hygiene . this point. Experiments 14 and36 indicate that, after section of the central nervous system distal tothe optic thalamus, no fever reaction results from the injection of a doseof pyrogen ordinarily sufficient to induce fever. The operation wasperformed under anaesthesia. After trephining the skull, an aneurismneedle was passed along the tentorium and the brain stem severedbelow the Optic Thalamus. The brain itself was not mutilated at all. The position of section was verified by post-mortem examination. It is, however, questionable whether these results are of muchvalue
The Journal of hygiene . this point. Experiments 14 and36 indicate that, after section of the central nervous system distal tothe optic thalamus, no fever reaction results from the injection of a doseof pyrogen ordinarily sufficient to induce fever. The operation wasperformed under anaesthesia. After trephining the skull, an aneurismneedle was passed along the tentorium and the brain stem severedbelow the Optic Thalamus. The brain itself was not mutilated at all. The position of section was verified by post-mortem examination. It is, however, questionable whether these results are of muchvalue as the animal was more or less in a condition of shock when thepyrogen was injected. Nature of the Fever-Producing Body. As previously cited experi-ments have shown, broth cultures of B. coli contain pyrogen, thoughin relatively small quantities. Similarly the washings of emulsions ofthis organism are also pyrogenetic, although the washings were foundto be bacteria free by microscopical examination (Experiment 59 6, fo4. 2^. 4 Chart 9. Metabolism in fever. Exp. 79. Date24. in. 13 Dry13-5° T. of air Rabbit59 C. Wet10° C. Weight1600 gms. 80 26. m. 13 15 11 00 1720 gms. 82 28. III. 13 12-5 10 43 1550 gms. 87 7. IV. 13 15-4 10-7 52 1870 gms. 90 9. IV. 13 14-5 10-3 59 1590 gms. Injection0-00018 gm. wet culture ( =00000176 gm. dry ) in 1 Ringer0-0001 gm. wet culture (=0-00001 gm. dry bacteria) in 1 Ringer0-00013 gm. sulphate powder (=0-000005 gm. dry bacteria) in 1 RingerTwo separate injections of pyrotoxin (Sebas- tiani) solution0-05 gm. sulphate powder (0-002 gm. dry bacteria) in 1 Ringer { denotes B. coli communis) 13—2 188 E.)j)(nnu)if<(I Studt/ of Fei^er Rabbit -il). As previously stated bacterial pyrogen resists fact was contirnied by experiment (see Experiment 45, Rabbits43 and 44). When kept in the form of paste exposed to the air, thepyrogen of B. (i/phosus gradually diminishes in power (
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Keywords: ., bookcentury1900, bookdecade1900, booksubjecthygiene, bookyear1901
