Molecular model of the homo 2-mer human polymerase theta (blue, greyish) complexed with a human ssDNA (single-stranded deoxyribonucleic acid, cyan). D

---

Molecular model of the homo 2-mer human polymerase theta (blue, greyish) complexed with a human ssDNA (single-stranded deoxyribonucleic acid, cyan). DNA double-strand breaks often leads to genomic instability and oncogenesis. Their repair mainly occurs through homologous recombination and non-homologous end joining. In homologous-recombination-deficient cells, dna, polymerase, deoxyribonucleic acid, theta becomes critical for double-stranded break repair via microhomology-mediated end joining, also termed theta-mediated end joining. DNA polymerase theta is synthetically lethal with BRCA1/2 and other homologous recombination factors, making it a potential therapeutic target in HR-deficient cancers.

---

Size: 4150px × 4150px
Photo credit: © ***DEPENDS ON PIC***/SCIENCE PHOTO LIBRARY / Alamy / Afripics
License: Licensed
Model Released: No

Keywords: -, acid, artwork, background, biochemical, biochemistry, break, cgi, deoxyribonucleic, digitally, dna, double-stranded, dsb, enzyme, enzymes, generated, hr, illustration, microhomology-mediated, model, molecular, nhej, polymerase, repair, space-filling, spacefilled, ssdna, structural, structure, target, therapeutic, theta, tmej, transferase, white