Intravenous injection in wound shock : being the Oliver-Sharpey lectures delivered before the Royal College of Physicians of London in May 1918 . e leg being cut in order to avoid vaso-motorreflexes, the number of drops per minute at anarterial pressure of 66 mm. was 60, at a pressure of54 mm. it was 40 (see Fig. 2). That is, whilethe blood pressure fell by 18 per cent., the rate ofblood flow fell by 33 per cent. These differentpressures were the top and bottom of Traube-Hering waves, and these followed one another atabout two to three minute intervals, so that theabsence of disturbing factors
Intravenous injection in wound shock : being the Oliver-Sharpey lectures delivered before the Royal College of Physicians of London in May 1918 . e leg being cut in order to avoid vaso-motorreflexes, the number of drops per minute at anarterial pressure of 66 mm. was 60, at a pressure of54 mm. it was 40 (see Fig. 2). That is, whilethe blood pressure fell by 18 per cent., the rate ofblood flow fell by 33 per cent. These differentpressures were the top and bottom of Traube-Hering waves, and these followed one another atabout two to three minute intervals, so that theabsence of disturbing factors was ensured. Theresults are not so striking as those of Gesell, butof the same significance from the practical point ofview, namely, that it is a matter of importance toaeplace even a comparatively small loss of blood, IN WOUND SHOCK 9 or to improve what might be supposed to be a fallof pressure of no particular consequence. Renal Secretion.—The kidney plays an im-portant part in the elimination of acid products andtoxic substances from the blood. It is well knownhow great is the dependence of its activity on thearterial blood Fig. 2.—Blood Flow through Leg of Cat as affected byChanges of Arterial Pressure. Nerves cut. The waves in the blood pressure curve (top tracing) werespontaneous. The middle line marks each drop of blood falling from the deepfemoral vein. The time tracing at the bottom marks each ten seconds. Pathological Changes in the Cells of variousorgans have been described as results of low bloodpressure. The effect of a short anaemia in pro-ducing a long-lasting cessation of renal activity isfamiliar. Some experiments made by Dr Jonescu(1909) with me, on the stimulation of salivarycentres by asphyxia, showed that want of oxygen, io INTRAVENOUS INJECTION whether due to deficiency in the air breathed or toa low blood pressure from haemorrhage, caused arapid decrease in the rate of secretion. Fig. 3illustrates the effect of the latter. Markwalder andSt
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