. The actinomycetes. Actinomycetales. 54 NATURE, FORMATION, AND ACTIVITIES candidin, amphotericin B, caiidicidiii, tri- chomycin, and perimycin. Pimaricin has the empirical formula C34H49NO14 and the following sti-ucture: heptaenes. Of the five hexaenes reported in the literature, four are said to ha\'e some kind of antil)acterial activity. The chemistry of the heptaenes has been H2X. -OH The nitrogen is present in the form of an studied chiefly by Borowski and coworkers amino group in a five-carbon sugar moiety, (1960). Amphotericin B and candidin are mycosamine. A large lactone ring of the x
. The actinomycetes. Actinomycetales. 54 NATURE, FORMATION, AND ACTIVITIES candidin, amphotericin B, caiidicidiii, tri- chomycin, and perimycin. Pimaricin has the empirical formula C34H49NO14 and the following sti-ucture: heptaenes. Of the five hexaenes reported in the literature, four are said to ha\'e some kind of antil)acterial activity. The chemistry of the heptaenes has been H2X. -OH The nitrogen is present in the form of an studied chiefly by Borowski and coworkers amino group in a five-carbon sugar moiety, (1960). Amphotericin B and candidin are mycosamine. A large lactone ring of the xevy closely related substances, each of type found in the bacterial macrolides, such which contains one atom of nitrogen located as erythromycin, is formed in part by the in the amino sugar, mycosamine. In contrast, tetraenic chromophore. A carl)oxyl and an candicidin, trichomycin, and perimycin have epoxide group are attached to the large twoaminogroupsper molecule. In candicidin lactone ring. Alycosamine is also present in and trichomycin, one of these amino groups the molecule of another tetraene, nystatin, is located in a mycosamine moiety and the and in the molecule of some of the hep- other in a p-aminoacetophenone moiety: taenes. Nystatin has a larger molecule than pimaricin; it has the empirical formula Lagosin and filipin are two pentaenes which do not contain nitrogen: CH3(CH2)4CHOH CHa—CO—r ^—NH2 Perimycin dilTers in that one of the amino groups is located in an amino sugar moiety. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Waksman, Selman A. (Selman Abraham), 1888-1973. Baltimore, Williams & Wilkins
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