Healthy and mutant Huntingtin protein sequence, computer illustration. Expansion of the CAG trinucleotide sequence in the htt gene causes production o
Healthy and mutant Huntingtin protein sequence, computer illustration. Expansion of the CAG trinucleotide sequence in the htt gene causes production of mutated Huntingtin protein, which contains polyglutamine expansion (polyQ), leading to neurodegeneration, atrophy of brain basal ganglia, involuntary movements and dementia.
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