. The endocrine organs; an introduction to the study of internal secretion . FIG. 98.—Effect of addition of liquor folliculi of cow to Lockes solution in which a cornu of ratuterus was suspended. Notice the increase of tone with cessation of rhythmic Locke the liquor folliculi was removed and Lockes solution substituted. with marked diminution of tone. Rarely this inhibitory effect rather thanincreased contraction is obtained with the other extracts. It appears probable from these observations that ovarian extracts con-tain two different kinds of autacoid acting upon plain muscle,
. The endocrine organs; an introduction to the study of internal secretion . FIG. 98.—Effect of addition of liquor folliculi of cow to Lockes solution in which a cornu of ratuterus was suspended. Notice the increase of tone with cessation of rhythmic Locke the liquor folliculi was removed and Lockes solution substituted. with marked diminution of tone. Rarely this inhibitory effect rather thanincreased contraction is obtained with the other extracts. It appears probable from these observations that ovarian extracts con-tain two different kinds of autacoid acting upon plain muscle, especially upon 144 The Endocrine Organs that of the uterus. One of these is a hormone, and either excites the muscleto contraction or renders it more excitable to the natural stimuli which areproducing the contractions; the other is a chalone, tending to prevent ordiminish the contractions. The difference of result obtained would depend uterus kidney carotid respira-tions time in 10signal. FlG. 99.—Effect of intravenous injection of extract of corpus luteum on uterus, kidney volume,blood-pressure, and respirations of cat. The small waves on the uterus curve are causedby the respirations. upon«the relative amount of one or other autacoid in a particular extract,and on the sensitiveness of the tissue under examination to the effects ofexcitatory or inhibitory agents. Whether the action is exercised throughnerve end-organs, or whether it is a direct effect upon the contractile tissue,is a point which it has not been easy to determine. On Milk Secretion.—One of the effects of intravenous injection inlactating animals of extract of corpus luteum is to provoke an outpouring Effects of Ovarian Extracts 145 of milk (Ott and Scott). This galactagogue action was found by Mackenzieto be absent in extracts of ovary minus corpus luteum. It resembles that
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