. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. R27 LABORATORY OF AQUATIC BIOMEDICINE (Staff SENIOR SCIENTIST Carol L Reinisch ADJUNCT SCIENTIST Raymond Stephens. Boston University POSTDOCTORAL RESEARCHERS Rachel Cox Jill Kreiling STUDENT Daniel Kabat VISITING SCIENTISTS Sylvie St Jean. Division of Fisheries and Oceans, Moncton, Canada Greg McCallum, Atlantic Veterinary College, Chartottetown, Prince Edward Island, Canada. This laboratory is dedicated to using marine invertebrates as biomedical models to study issues of health at •%£. \ IBM the molecular level. In an embr
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. R27 LABORATORY OF AQUATIC BIOMEDICINE (Staff SENIOR SCIENTIST Carol L Reinisch ADJUNCT SCIENTIST Raymond Stephens. Boston University POSTDOCTORAL RESEARCHERS Rachel Cox Jill Kreiling STUDENT Daniel Kabat VISITING SCIENTISTS Sylvie St Jean. Division of Fisheries and Oceans, Moncton, Canada Greg McCallum, Atlantic Veterinary College, Chartottetown, Prince Edward Island, Canada. This laboratory is dedicated to using marine invertebrates as biomedical models to study issues of health at •%£. \ IBM the molecular level. In an embryo model, we are examining how industrial chemicals influence neural development, plasticity, and function. Specifically, polychlorinated biphenyls (PCBs) or chemicals found in the wells of Brick, NJ, a site of autism in children, are added to developing clam embryos and neuronal development assessed. We evaluate how chemicals pinpoint molecular targets such as the p53 gene family. We are dissecting how p53 gene expression and function are altered by chemical exposure. Currently we are focusing on the p73 gene, which is critically impor- tant in regulating neuronal development. The second line of research examines the induction of leukemia in clams or mussels at industrially polluted sites. We have developed in vitro technology to grow the tumor cells for genetic analyses. (Supported by the Alternatives Research and Development.) In collaboration with the Division of Fisheries and Oceans (DFO) Canada, we are examining the rate of induction of leukemia in Myt/7us edulis, the blue mussel. Mussels are placed in both clean and dirty sites in Canadian harbors. Five to six months later, the animals are retrieved and assessed for cancer using a leukemia-specific monoclonal anti- body generated by this laboratory. Thus far we have determined that exposure of mussels to PAHs, PCBs, heavy metals, and other industrial compounds increases both the rate and severity of leukemia. This res
Size: 1689px × 1479px
Photo credit: © Library Book Collection / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
