American journal of pharmacy . Tracing i-C. The same tracing later. strength, the excursions become gradually smaller until the heartfinally stops. Records of the heart taken in this manner frequentlyshow a one to two rhythm between the auricles and the ventricles inthe latter stages of poisoning (see tracing i-I>); this indicatesthat adonis decreases the power of conduction between the auriclesand the ventricles, in the same manner as does digitalis. The trac-ings I-A, B, C, are very typical of the effect of adonis upon thehearts rate of beat. The heart is always slowed until it reaches th
American journal of pharmacy . Tracing i-C. The same tracing later. strength, the excursions become gradually smaller until the heartfinally stops. Records of the heart taken in this manner frequentlyshow a one to two rhythm between the auricles and the ventricles inthe latter stages of poisoning (see tracing i-I>); this indicatesthat adonis decreases the power of conduction between the auriclesand the ventricles, in the same manner as does digitalis. The trac-ings I-A, B, C, are very typical of the effect of adonis upon thehearts rate of beat. The heart is always slowed until it reaches thetoxic stage when it becomes rapid and irregular. When the frogsheart has been stopped by adonis, it presents a very characteristicpicture, namely, that the ventricular walls are firmly Contractedso that they appear quite pale in color, the auricles being widely Am. Jour. , 1920. Action of Adonis Vernalis. 705. Tracing i-D. Showing the one to tworythms often displayed after the appHca-tion of adonis. The time is marked inseconds, the lever moves upwards in sys-tole and downwards in diastole. dilated and filled with dark unoxygenated blood. In short thehearts appear to be typical digitalis hearts. Since the frog hearts which had been poisoned with adonis, pre-sented the typical digitalis picture, it seemed reasonable that adoniscould be assayed by the one-hour frog method which is official fordigitalis. The information with regard to adonis has been derived fromwork done upon two lots of the drug, which we have called Drug Aand Drug B. Alcoholic tinctures were made from these drugs atdifferent times and they were assayed as follows: Drug A. Per cent, of alcohol in the Toxicity, or the minimum systolic dose THE ASSAY OF ADONIS. menstruum used. (M. S. D.) per gram of frog. 95 cc. 95 cc. 80 cc. 70 cc. 60 cc. 50 cc. This makes the average toxicity
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