. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . KgCTW!^iiiiii5i5iii5ii555555BB«wwiBBMaMg^BS FIG. 14Response to , 1:100,000 adrenalin in the monkey. followed by dilatation of the intestine. Marked dilata-tion of the limb. (Reduced %.) clam]3ing the aorta too high up, as that has frequentlybeen the case in cats. On the other hand injection ofthe hormone into the perfusion fluid easily produceddilatation. The explanation, therefore, might be thatthe vasodilator myoneural junction and not the gan- HARTMAN, KILBORN AND LANG 137 gliar ineclianisin was
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . KgCTW!^iiiiii5i5iii5ii555555BB«wwiBBMaMg^BS FIG. 14Response to , 1:100,000 adrenalin in the monkey. followed by dilatation of the intestine. Marked dilata-tion of the limb. (Reduced %.) clam]3ing the aorta too high up, as that has frequentlybeen the case in cats. On the other hand injection ofthe hormone into the perfusion fluid easily produceddilatation. The explanation, therefore, might be thatthe vasodilator myoneural junction and not the gan- HARTMAN, KILBORN AND LANG 137 gliar ineclianisin was the source of the are inclined to doubt this as being typical, forthere is no reason to believe that the monkey is dif-ferent from the eat and dog in which the gangliarmechanism is an important source of adrenalin vaso-dilatation (13). The intestinal mechanism in the monkev worked. -=?fi*»^ FIG. 15Effect of a larger dose of adrenalin, , 1:10,000 in themonkey. (Reduced %.) PIG. 16Reversal in the limb produced by a large dose of adrenalin, , 1:10,000 in the monkey. (Reduced %.) 138 ADRENALIN IN VERTEBRATES very well (Figs. 14 and 15) until large doses of adren-alin were used when constriction only was obtained(Fig. 16). A fall in blood pressure was obtained from the in-jection of small doses of adrenalin (Fig. 13), but assometimes happens in cats or dogs the fall becamesmall or almost disappeared after a few doses hadbeen injected (Fig. 14). DISCUSSION So far as we know the blood vessels of all verte-brates lower than mammals are constricted by adren-alin. In the frog Burket (17) found that the constrictoreffect of succeeding doses of adrenalin rapidly de-clines until there remains only a very small also noted that the rise in pressure lasts muchlonger than in the cat. Our observations upon theturtle are somewhat similar, there being a ra
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