. Contributions from the Department of Neurology and the Laboratory of Neuropathology (reprints). or disintegrative changes. Nopart of the section is free from fibers. Their normal appearanceis most interesting since the cases hitherto reported have allshown decided structural changes. The Pyramids.—The two pyramids arc so siinilar that one AXISXVLINDERS L\ CASES OF GLIOMA CEREBRI 141 description will serve for both. Figs. 7 and 8 represent the leftanterior pyramid stained by the Weigert and Bielschowsky meth-ods respectively. In neither case are there definite degenerativechanges. The Weigert
. Contributions from the Department of Neurology and the Laboratory of Neuropathology (reprints). or disintegrative changes. Nopart of the section is free from fibers. Their normal appearanceis most interesting since the cases hitherto reported have allshown decided structural changes. The Pyramids.—The two pyramids arc so siinilar that one AXISXVLINDERS L\ CASES OF GLIOMA CEREBRI 141 description will serve for both. Figs. 7 and 8 represent the leftanterior pyramid stained by the Weigert and Bielschowsky meth-ods respectively. In neither case are there definite degenerativechanges. The Weigert preparation, in particular, is quite normallooking, the fibers show no swelling or beading, and are presentin sufficient numbers. The silver preparation, however, showssome swelling of the axis-cylinders in places. There is no frag-mentation and no part of the section is devoid of fibers. A trans-verse section of the anterior pyramids stained by the Weigertmethod was studied from a preparation belonging to Dr. Spiller,which he kindly let me use. There was no degeneration in 3?^ Fig. 7. Weigert preparation from left anterior pvramid cut longi-tudinally. Case 5. Oc. i, Ob. i. Fig. 8. Bielschowsky preparation from same block of tissue as Oc. I, Ob. i. For the sake of completeness and to determine whether theremight be some reaction a distance, sections were made fromthe right and left paracentral lobules in order to study the Betzcells. They were stained by the Bielschowsky and thionin meth-ods. There was some central chromotolysis in the thionin prepa-ration, though not to a marked degree, and the intracellularfibrils more disintegrating in a few cells. Considering the ageof the patient and the increased cerebral pressure with probablecirculatory disturbances, such observations are of little value. Atany rate, the majority of the cells were perfectly normal. The first criticism from inquiring minds will naturally beconcerning the silver preparations. Are
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