. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . form a pool of the solution of adrenahn around the ganglion. Thesolution was simply poured into the pocket and between each applica-tion it was washed away with normal saline solution, which was after-wards removed by sponging. The following results were obtained:A small dilatation of the intestine was produced by a 1: 20,000 solution,ten minutes later a 1: 5000 solution produced a more marked dilata-tion and finally a 1: 1000 solution produced a dilatation which con-tinued to increase over a longer period than the prec
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . form a pool of the solution of adrenahn around the ganglion. Thesolution was simply poured into the pocket and between each applica-tion it was washed away with normal saline solution, which was after-wards removed by sponging. The following results were obtained:A small dilatation of the intestine was produced by a 1: 20,000 solution,ten minutes later a 1: 5000 solution produced a more marked dilata-tion and finally a 1: 1000 solution produced a dilatation which con-tinued to increase over a longer period than the preceding, althoughthe first effects were about the same (fig. 12). In no case was thereany appreciable effect upon the blood pressure. In view of the evidence advanced above, that the dorsal root gangliacontain an adrenalin vasodilator mechanism for the hind limb, it wasthought possible that there might be a similar one for the intestineand that this might respond to direct application of a solution of adren-alin. With the results of Bayliss (5) in mind we judged that the. Fig. 11. Failure of intestinal dilatation from adrenalin due to paralysis ofthe*mechanism by nicotine. Upper record, response to 2 cc, 1: 100,000 adrenalinbefore nicotine. Lower record, response to 2 cc, 1: 100,000 adrenalin afterinjection of nicotine in the same animal (cat, weight kgm.) Base of bellows20 mm. X 21 mm. (Reduced one-fourth.) [182 LOCATION OF ADRENALIN VASODILATOR MECHANISMS 183 dorsal root ganglia most likely to cause this reaction were those ofthe twelfth and thirteenth thoracic nerves. We have been able toshow that such a mechanism exists, although several of our experi-
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