. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. B log [YFAFPRQa (M)]. -13 -12 -11 -10 -9 -8 -7 -6 log [YFAFPRQa (M)] Figure 2. (A) Dose-response curves illustrating the antagonistic effect of YFAFPRQamide on the dopamine- (DA-) induced inhibition of lateral cilia. Ordinate: the fractional difference between lateral cilia exposed to 5 x 1(T7 M DA plus various concentrations of YFAFPRQamide. and lateral cilia exposed only to 5 x ](T7 M DA. Peptides were added 10 min before the cilia were exposed to DA. The regression lines were generated at the times indicated after th
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. B log [YFAFPRQa (M)]. -13 -12 -11 -10 -9 -8 -7 -6 log [YFAFPRQa (M)] Figure 2. (A) Dose-response curves illustrating the antagonistic effect of YFAFPRQamide on the dopamine- (DA-) induced inhibition of lateral cilia. Ordinate: the fractional difference between lateral cilia exposed to 5 x 1(T7 M DA plus various concentrations of YFAFPRQamide. and lateral cilia exposed only to 5 x ](T7 M DA. Peptides were added 10 min before the cilia were exposed to DA. The regression lines were generated at the times indicated after the addition of DA. The slope parameter (/31) of the line at 10 min is not significantly different from 0. Data points are omitted for clarity. (B) The regression line at 60 min with data points included. The mean EC5() for these times is X 10 '' M (± X 10 l2 M). To determine whether the latency in the effect of YFAFPRQamide might reflect the permeability of the gills to the peptide, the concentration of DA was increased, from 5 X 10 ~7 M. to 10 " M. If the latency were due primarily to the low permeability of the peptide, then increasing the dose of DA should only increase the EC,,, of YFAFPRQ- amide and not alter the time course of the response. In fact, the threshold for the effect of the peptide increased from. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Marine Biological Laboratory (Woods Hole, Mass. ); Marine Biological Laboratory (Woods Hole, Mass. ). Annual report 1907/08-1952; Lillie, Frank Rattray, 1870-1947; Moore, Carl Richard, 1892-; Redfield, Alfred Clarence, 1890-1983. Woods Hole, Mass. : Marine Biological Laboratory
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