. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. COOR' VI R'- H W/R'--CH3 ///R/=-C5H1l R--C6H13. *R'=-CH X/VR~ X R — • C/Hg XV R — R'=-QH9(tert) XVI R'-Ch^Cgl-^Br FIGURE 1. changes in concentration. Serial dilution were used to determine the range of activity of each compound; then, assays within this concentration range permitted a more accurate determination of activity. If the compounds did not show any activity below 100 /^g in topical assays or 1000 pg in injection assays, no further tests were performed. The compounds (I)-(III) were prepared by conventional methods;
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. COOR' VI R'- H W/R'--CH3 ///R/=-C5H1l R--C6H13. *R'=-CH X/VR~ X R — • C/Hg XV R — R'=-QH9(tert) XVI R'-Ch^Cgl-^Br FIGURE 1. changes in concentration. Serial dilution were used to determine the range of activity of each compound; then, assays within this concentration range permitted a more accurate determination of activity. If the compounds did not show any activity below 100 /^g in topical assays or 1000 pg in injection assays, no further tests were performed. The compounds (I)-(III) were prepared by conventional methods; (IV) and (V) were synthesized by alkylation of silver salts of farnesenic acid with cyclohexyl and benzyl iodide respectively. For the synthesis of esters (VII)- (XVI) we used crystalline £ acid (VI) (trans- 3,7,ll-trimethyl-7,ll-dichloro-2-dodecenic acid, 93-94° (Romafiuk and Sorm, 1968). The acid was prepared by bubbling gaseous hydrogen chloride through an acetic acid solution of farnesenic acid. It was then treated with thionyl chloride to produce the acid chloride (Via) which, in turn, was reacted with various alcohols to give the corresponding trans dichloro-esters. Farnesol and farnesyl methyl ether were commercial samples which were checked for purity by gas chromatography. Methyl 10,11-epoxyfarnesoate was made in a usual way by action of perphthalic acid on methyl farnesoate. The preparation of p-(dimethyl-hexyl) benzoic acid derivatives has already been de- scribed (Slama ct al., 1968). The synthetic ^/-juvenile hormone was a gift from Dr. H. Roller. "Juvabione" (methyl todomatuate) was the natural product isolated from balsam fir wood (Cerny et al., 1967). RESULTS AND DISCUSSION The results are summarized in Table I. Farnesenic acid (I) had generally low activity, one unit being in all cases much greater than 100 /u,g. Its methyl. Please note that these images are extracted from scanned page images that may have b
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
