Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . pindle-cell fonns of the tumor are fre-quently bossed or tuberous; this latter character is due to multi-centric nodules that have developed around, or contiguous to, theprimary mass. 24 sare J?^^^^ t^^-^ 354 GENERAL PATHOLOGY. Spindle-cell sarcomata are most common in the periosteum, fasciae,eye, antrumi, breast, and testicle, but may occur in any connective tumors tend rapidly to infiltrate the surrounding tissue and torecur locally after removal. (b) Large Spindle-cell
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . pindle-cell fonns of the tumor are fre-quently bossed or tuberous; this latter character is due to multi-centric nodules that have developed around, or contiguous to, theprimary mass. 24 sare J?^^^^ t^^-^ 354 GENERAL PATHOLOGY. Spindle-cell sarcomata are most common in the periosteum, fasciae,eye, antrumi, breast, and testicle, but may occur in any connective tumors tend rapidly to infiltrate the surrounding tissue and torecur locally after removal. (b) Large Spindle-cell Sarcoma.—This differs from the small spindle-cell variety in that the cells are larger, with prominent nuclei and nu-cleoli, which are frequently multiple; there is very little intercellularsubstance, with slight or, it may be, no fibrillation. The tumor is likelyto be very soft, and is sometimes stained by extravasated blood; thegrowth is rapid and the neoplasm very malignant. These tumors fre-quently become osseous (osteosarcoma or osteoid sarcoma), especiallywhen occurring in the periosteum or Fig. 199.—Sarcoma of^the Mammary Gland; Tumor of Several Years Duration; Patient Thirty-five Years of Age. .4. Nipple that appears slightly retracted; this appearance is not due to a pulling-in of the nipjile, as in carcinoma,but results from the forward projection of the skin caused by the enlarging neoplasm. B. One f the manysecondary bosses over which the skin is thin and shining. These nodules result from the polycenj-ic local dis-semination. 3. Giant-cell Sarcoma (Myeloid Sarcoma).—This variety resemblesthe spindle-cell growths, and usually occurs in connection with tumors contain many large polynucleated cells (see Fig. 201),and fusiform cells like those of the spindle-cell varieties; indeed, giant-cell sarcomata are practically all mixed-cell tumors in which the giant-cells constitute more or less .conspicuous elements. In addition to thepolymorphism of t
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