. The thyroid gland in health and disease. gular and uniform, high columnar epithelium ; the absence of true colloidand the generalized increase of stroma. (Reproduced by courtesy of Dr. DavidMarine, Cleveland.) over the age of forty years, in whom senile atrophy mayalready have begun. Under these circumstances no swellingof the gland will occur at any stage of the process. In thisway cases of myxcedema or hypothyroidism may arise in yoiuigpeople as well as in adults, the severity of the resultantsymptoms depending on the extent of the cell-death and fibrosis(figs. 23, 24). In other cases wher
. The thyroid gland in health and disease. gular and uniform, high columnar epithelium ; the absence of true colloidand the generalized increase of stroma. (Reproduced by courtesy of Dr. DavidMarine, Cleveland.) over the age of forty years, in whom senile atrophy mayalready have begun. Under these circumstances no swellingof the gland will occur at any stage of the process. In thisway cases of myxcedema or hypothyroidism may arise in yoiuigpeople as well as in adults, the severity of the resultantsymptoms depending on the extent of the cell-death and fibrosis(figs. 23, 24). In other cases where conditions of malnutrition and thvroid COLLOID GOITRE 67 impoverishment are not paramount, the hyperplastic processtakes one of two courses ; 1. It reverts to the colloid state, forming the so-called colloid goitre, or 2. It continues without any period of rest, ultimately terminating in cell-exhaustion and the first event, the reversion to the colloid type followsthat course which has been described as a normal process of. Fig. 16.—Section of goitrous thyroid in rat. Due to the contamination of theanimals food with fsecss of goitrous individual. Note high epithelium, irregularacini, absence of colloid, increase of fibrous stroma, marked hyperplasia of paren-chyma cells. X 166. secretion in an earlier part of the work. The old and the newvesicles becom^e distended with colloid, absorption of a numberof the new-formed elements occurs, and iodine is again storedin the colloid (figs. 17, 18).i The gland reverts to a statewhich may approach very nearly to normal, but it shows ^ In goitre produced experimentally in rats by means of faecal material or bycultures from fseces, the contintious administration of these toxic materials does notpermit the gland to revert to the colloid state. Under the conditions of the experi-ment they are allowed no period of rest, consequently no colloid accumulates in thehyperplastic organ.—R. McC. 68 PATHOLOGY the scars of its encou
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