AMAarchives of neurology & psychiatry . e the section a deeply colored places the greatly swollen ganglion cells were pressed so closelytogether as to form giant cells containing several nuclei. It was notalways easy to differentiate between the nuclei of the host and thoseof the included cancer cells. Some of the most damaged ganglion cells appeared structureless,colorless, devoid of chromatin and often without inclusions (Fig. 4) HASSIX-SIXGER—CEREBRAL CARCIXOMA 161 but with a large pale nucleus, free from chromatin but possessing amembrane and visible nucleolus. Many could be
AMAarchives of neurology & psychiatry . e the section a deeply colored places the greatly swollen ganglion cells were pressed so closelytogether as to form giant cells containing several nuclei. It was notalways easy to differentiate between the nuclei of the host and thoseof the included cancer cells. Some of the most damaged ganglion cells appeared structureless,colorless, devoid of chromatin and often without inclusions (Fig. 4) HASSIX-SIXGER—CEREBRAL CARCIXOMA 161 but with a large pale nucleus, free from chromatin but possessing amembrane and visible nucleolus. Many could be recognized only by acareful study of the numerous transition types. So manifold werethese that description is impossible. Some conception of the ;ize and general appearance may be gained from Figs. 3. 4 and 5. The]jrocess in general appeared to be progressive liquefaction and tumefac-tion with neuronophagy, the invaders being cancer cells, lymphocytesand polymorjjhonuclear leukocytes, the first being by far the Fig. 5.—In the center of the photomicrograph is a large swollen ganglioncell invested with a connective tissue membrane. It contains large globules oflipoids and four vacuoles in which cancer cells can be seen with a hand lens;at (7 G are liquefied ganglion cells; the apical dendron of the upper one appearsintense!}- dark and contains the nucleus. The rest of the picture shows numerouscancer nuclei within greath changed and liquefied ganglion-cells: some of theseappear entireh- colorless and empty. Lichtgrvin-f uchsin; X ^SO. It is noteworthy that within the tumor mass there was no glialproliferation. Instead, connective tissue fibers enclosed groups of nervecells or even single cells. In the latter case the ganglion cell appearedto be invested with a connective tissue membrane (Fig. 5). Theconnective tissue was derived from the blood vessels and pial pro- 162 ARCIIIlES or M-JKOLOCy A\D PSVCHLITRV longations and often formed broad strands whic
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