. Bulletin of the Department of Agriculture. Agriculture; Agriculture. <&&&'<&*ru Contribution from the Bureau of Chemistry CARL L. ALSBERG, Chief. jfUr^JL Washington, D. C. November 12, 1920 TOXICITY OF BARIUM CARBONATE TO RATS. By Erich W. Schwartze, Junior Pharmacologist, Pharmacological Laboratory, CONTENTS. Purpose of investigation Previous investigations Experimental procedure Results of experimental work Minimum efficient concentration of barium carbonate Page. 1 1 3 4 Results of experimental work on other barium compounds 9 T oxicity of barium carbonate to an
. Bulletin of the Department of Agriculture. Agriculture; Agriculture. <&&&'<&*ru Contribution from the Bureau of Chemistry CARL L. ALSBERG, Chief. jfUr^JL Washington, D. C. November 12, 1920 TOXICITY OF BARIUM CARBONATE TO RATS. By Erich W. Schwartze, Junior Pharmacologist, Pharmacological Laboratory, CONTENTS. Purpose of investigation Previous investigations Experimental procedure Results of experimental work Minimum efficient concentration of barium carbonate Page. 1 1 3 4 Results of experimental work on other barium compounds 9 T oxicity of barium carbonate to animals other than rats 9 Conclusions 9 6 Bibliography. 10 PURPOSE OF INVESTIGATION. A series of experiments on the toxicity of various substances to rats and their suitability for poisoning these animals was undertaken, in 1918, at the request of the Bureau of Biological Survey of the United States Department of Agriculture, for the purpose of obtain- ing toxicological data for use in connection with the rat-extermina- tion work in the zone of occupation of the American Expeditionary Forces. Although this incentive ceased with the signing of the armis- tice, the studies have been continued because of their importance to agricultural economics as well as to the public health. PREVIOUS INVESTIGATIONS. The literature contains no references to work dealing with the toxicity of barium carbonate to rats, in spite of the fact that many articles give directions for its use as a rat poison and discuss its tox- icity to other animals. The earliest communication which is of in- terest here is one by Crampe (5),1 who recommended 20 per cent barium carbonate in bait for poisoning field mice. Lantz's (9) ba- rium carbonate formula also calls for 20 per cent of this substance. Recently White (20) has reported good results from poisoning Mus rattus by the use of 25 per cent of barium carbonate. This concen- tration, however, was ultimately diluted, as water was added to the barium carbonate bai
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