. Bacterial pyrogens; particularly pyrogenic polysaccharides of bacterial origin : an annotated bibliography. Pyrogens. 81 - 1 9 3 6 - 244. SHEAR, M. J. and ANDERVONT, H. B. Chemical treatment of tumors. III, Separation of hemorrhaee- produclng fraction of B. coll filtrate Proc. Soc. Exper. Blol„ Med. 34:323-325, I936 A method Is described for the separation of the tumor-hemorr- hage producing fraction of B. coll filtrate from toxic and Inert contaminants. The method Involves centrlfugatlon, filtration, alkaline precipitation, and the removal of calcium by acidi- fication with HCl and precipit
. Bacterial pyrogens; particularly pyrogenic polysaccharides of bacterial origin : an annotated bibliography. Pyrogens. 81 - 1 9 3 6 - 244. SHEAR, M. J. and ANDERVONT, H. B. Chemical treatment of tumors. III, Separation of hemorrhaee- produclng fraction of B. coll filtrate Proc. Soc. Exper. Blol„ Med. 34:323-325, I936 A method Is described for the separation of the tumor-hemorr- hage producing fraction of B. coll filtrate from toxic and Inert contaminants. The method Involves centrlfugatlon, filtration, alkaline precipitation, and the removal of calcium by acidi- fication with HCl and precipitation with alcohol. The final product was a water-soluble fraction, highly potent for the production of mouse tumor hemorrhage In amounts as low as cc, of a 1;100 dilution of a stock solution containing 22 mg. per cc. of the active fraction. 245. SHWARTZMAN, G. Reactivity of malignant neoplasms to bacterial filtrates. II, Relation of mortality to hemorrhagic necrosis and regression elicited by certain bacterial filtrates Arch, Path. 21:509-524, I936 Mice bearing 12-day-old sarcoma I80 implants were injected intra- venously, intra-oeritoneally or subcutaneously with one of the following bacterial filtrates: meningococcus "agar washlngs'j B. enteritidis. B. coll, E, typhosa,Staphylococcus aureus. Streptococcus hemolytic us and the tubercle bacillus. The ability of the preparations to elicit the Shwartzman phenomenon in rabbits was determined shortly before parenteral injection. E. typhosa and meningococcal filtrates were more toxic for the tumor-bearing mouse than for normal animals; filtrates of B, enteritidis were toxic for both normal and tumor-bearing test animals. All three were potent agents for tumor destruction. Bo coll, Str, hemolytlcus and tubercle bacillus filtrates pro- duced only slight changes in tumor tissue. Staphylococcus aureus filtrate produced no changes. Since all filtrates were highly toxic, it was evident that the lethal effects and tumor-des- tr
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