. The diseases of children : medical and surgical. oubtful : they are always suggestive of hereditarysyphilis. As chronic hydrocephalus is often associated with the meningitis,a diagnosis of hydrocephalus is piobably all that can be made during life. A meningitis during intra-uterine life, by interfering with the growth anddevelopment of the brain, may produce various results, such as hydrocephalus,sclerosis, or an abnormally small brain. Thus in a case^ of Dr. T. Barlows,in an infant dying at seven weeks of age, the head measured only lo^ inchesround, and the brain weighed only 9 drachms ; th
. The diseases of children : medical and surgical. oubtful : they are always suggestive of hereditarysyphilis. As chronic hydrocephalus is often associated with the meningitis,a diagnosis of hydrocephalus is piobably all that can be made during life. A meningitis during intra-uterine life, by interfering with the growth anddevelopment of the brain, may produce various results, such as hydrocephalus,sclerosis, or an abnormally small brain. Thus in a case^ of Dr. T. Barlows,in an infant dying at seven weeks of age, the head measured only lo^ inchesround, and the brain weighed only 9 drachms ; the convolutions werehardly recognisable over the greater part of the convexity, and the piamater and cortex beneath it were invaded with calcareous plates ; thechoroid plexuses of the lateral ventricles were also partially calcified. Inthis case there seems to have been an intra-uterine meningitis, followed bycalcification of the effused lymph and some atrophy of the subjacent braintissue. In the following case there had been apparently a meningo-. Fig. 96.—Microcephalic infant. Syphilitic infantfour weeks old. (See case.) From a photographby Mr. J. Hepworth. 1 Lancet, January 1895, p. 154. - Path. Tra7is. vol. xxxviii. p. 8. Chronic Meninpitis 483 encephalitis occurring during fetal life giving rise to sclerosis ; the infantwas syphilitic. The father of the infant suffered from sore throat, rash, and serpiginous ulceration ofhis legs. The mother, when pregnant, suffered from sore throat, and has had a squamoussyphilide on her face ; an infant born subsequently to the patient suffered from coryza andeclampsia. The infant was first seen when two weeks old : it was microcephalic, its headmeasuring loi inches in circumference (see fig. 96), it suffered from coryza and was idiotic, being unable to recognise anything. The fits continued, both arms and legsbecame paretic and later spastic. It died at five months of age. The brain weighed 3J oz.(after having been in weak
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