General and dental pathology with special reference to etiology and pathologic anatomy; a treatise for students and practitioners . pon a scaffold) are all processessimilar essentially to healing by first intention. The foreignbody may be softened and absorbed, or encapsuled (surroundedby dense fibrous tissue). When repair processes are relatively extensive or prolonged,giant cells—the giant cells of repair are found. They origi- 10S GENERAL PATHOLOGY nate either by division of nuclei without division of cytoplasm,or by confluence of cells. Many of them are phagocytic. Repair of a slight wound
General and dental pathology with special reference to etiology and pathologic anatomy; a treatise for students and practitioners . pon a scaffold) are all processessimilar essentially to healing by first intention. The foreignbody may be softened and absorbed, or encapsuled (surroundedby dense fibrous tissue). When repair processes are relatively extensive or prolonged,giant cells—the giant cells of repair are found. They origi- 10S GENERAL PATHOLOGY nate either by division of nuclei without division of cytoplasm,or by confluence of cells. Many of them are phagocytic. Repair of a slight wound in avascular tissues, as the cornea,may occur directly by proliferation of the lost cells, withoutthe essential phenomena of inflammation. Regeneration Regeneration is the formation of new tissue to replace thatwhich has been lost. Physiologic regeneration occurs constantly either to counter-balance the loss from wear and tear, or to form new cells (in ex-cess of those destroyed) in the process of growth. Pathologic regeneration is often atypical and usually exces-sive. The etiology is not known. The cells have an inherent. Fig. 29.—Fibroblasts forming fibrous tissue. (Ziegler.) tendency to multiply, with some restraining influence. In dis-ease there may be stimulation of reproduction by toxic productsor other agencies, and a reduction of restraint by removal of pres-sure, etc. Pathologic Anatomy.—The cells swell, and multiply by mito-sis, or rarely by amitosis. The latter is supposed to be a ret-rograde process in every instance. The cells subsequentlyform their characteristic intercellular substance. The less specialized a tissue may be and the younger the or-ganism, the more capable it is of regeneration, , the connec-tive tissue of an organ will always outstrip the parenchyma, ifthe latter regenerates at all. Pathologic Regeneration.—In connective tissue, the cells swelland multiply by mitosis. The new cells are round or oval withpaler nuclei than normal, and o
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Keywords: ., bookcentury1900, bookdecade1920, booksubjectpathology, bookyear19
