. Diseases of bones and joints . off from the diseased end by amass of dense bone. The neighboring joint may be the seat of a se-rous exudate. In some instances the inflammationmay make its way into the joint, causing a suppu-rative arthritis. Marrow Under the microscope the marrow is seen to be Changesthe seat of an intense inflammation, and containsnests of pus cocci, abscesses, areas of round eel?infiltration, etc. In places the marrow undergoesa fibrous change. As the disease spreads, the bone trabecular inplaces show productive, in places rarefying inflam-mation. Many of them are dead. So


. Diseases of bones and joints . off from the diseased end by amass of dense bone. The neighboring joint may be the seat of a se-rous exudate. In some instances the inflammationmay make its way into the joint, causing a suppu-rative arthritis. Marrow Under the microscope the marrow is seen to be Changesthe seat of an intense inflammation, and containsnests of pus cocci, abscesses, areas of round eel?infiltration, etc. In places the marrow undergoesa fibrous change. As the disease spreads, the bone trabecular inplaces show productive, in places rarefying inflam-mation. Many of them are dead. Some of thedead trabecular in the less active cases are lined b>osteoid tissue, showing the effort of the still livingmarrow to repair the damage done. When the lyo DISEASES OF BONES AND JOINTS morbid process has run its course, then all signs ofactivity cease in the dead structures. When an acute purulent inflammation has runits course in the soft tissues, healing is accom-plished by a filling of scar tissue, but in osteomye-. Fig. suppurative osteomyelitis, diffuse form, in a boy of 7. litis this is impossible. Whether the pus have beenlet out with a knife, or whether spontaneous dis-charge have taken place, the piece of necrotic boneshaft lies in its fibrous periosteal envelope, withwhich it may be adherent in places, attached at oneor both ends to living bone. In time nature willseparate the dead from the living bone, but if the DISEASES OF BONES AND JOINTS 171 destruction have been extensive, the dead seques-trum cannot be thrown off through the compara-tively small openings in the periosteum, but re- Mechanicalmains indefinitely locked up in a shell of new bone(the involucrum) built up around it by the activityof the inner layer of the periosteum. This is theso-called chronic stage of osteomyelitis, but inpoint of fact there is no active marrow inflamma-tion. The disease has run its course, and thewound is prevented from healing by a mechanicalobstruction. CIRCU


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Keywords: ., bookcentury1900, bookdecade1910, booksubjectbon, booksubjectbones