. The practice of medicine; a text-book for practitioners and students, with special reference to diagnosis and treatment . mb and its persistent ap-proximation to the second metacarpal bone produces the so-called ape-hand. Simultaneously, or almost simultaneously, the interossei begin PROGRESSIVE SPINAL MUSCULAR ATROPHY 941 to waste, producing conspicuous depressions between the metacarpalbones, associated with loss of power to extend completely the terminalphalanges of the fingers. Atrophy of the lumbricales follows, producinga flattening of the hollow of the hand. The ultimate result is the


. The practice of medicine; a text-book for practitioners and students, with special reference to diagnosis and treatment . mb and its persistent ap-proximation to the second metacarpal bone produces the so-called ape-hand. Simultaneously, or almost simultaneously, the interossei begin PROGRESSIVE SPINAL MUSCULAR ATROPHY 941 to waste, producing conspicuous depressions between the metacarpalbones, associated with loss of power to extend completely the terminalphalanges of the fingers. Atrophy of the lumbricales follows, producinga flattening of the hollow of the hand. The ultimate result is the char-acteristic main en griffe of Duchenne, in which the extensor tendons onthe dorsum of the hand, and the flexors in the palm, may become asdistinct as if dissected out. From the hand the wasting creeps up the forearm and thence to thearm, or it may skip the forearm and pass into the arm, sparing usuallythe triceps extensor. In the forearm the muscles on the extensor (ex-ternal) side are usually first aftected, then the abductor poUicis and ex-tensor longus poUicis, and later the supinators and flexors. It may come.


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