. A study of the causes underlying the origin of human monsters : third contribution to the study of the pathology of human embryos . ection of the vesicle, showing the irregularthickening of the ectoderm and entoderm. 158 MALL. [Vol. XIX. borders. The mesoderm is hypertrophic. The inner layeris irregular, thick and thin, with a tubular branching processwhich extends to the stem of the vesicle. There are bloodislands in the vesicle and stalk, and the vessels extend to thevilli of the chorion. There are migrating cells in the tissueof the pedicle. The syncytial layer is very extensive, forming
. A study of the causes underlying the origin of human monsters : third contribution to the study of the pathology of human embryos . ection of the vesicle, showing the irregularthickening of the ectoderm and entoderm. 158 MALL. [Vol. XIX. borders. The mesoderm is hypertrophic. The inner layeris irregular, thick and thin, with a tubular branching processwhich extends to the stem of the vesicle. There are bloodislands in the vesicle and stalk, and the vessels extend to thevilli of the chorion. There are migrating cells in the tissueof the pedicle. The syncytial layer is very extensive, forming large budsupon the chorion as well as upon the villi. At points thesebuds coalesce to form islands, the centers of which are com-posed of necrotic mass filled with fragmented nuclei. No. 25. Chorion, 25 mm. in diameter, with a pedicle within 6 and 2 mm. in diameter. Dr. J. W. Lord, Baltimore. The ovum is covered entirely with long villi, and has ahemorrhage on one side of it. The pedicle within has all ofthe characteristics of the umbilical cord of an embryo fiveweeks old. There is no trace of an embryo, but there are a. Fig. 25.—Section through the umbilical cord and amnion at their attach-ment to the chorion. X 10 times. number of cells at the free end of the pedicle, which also hasa ragged edge. The amnion lines the entire coelom and isreflected over the pedicle just as it would be over the normalcord. Sections show that the club-shaped cylindrical body is infact the cord with its blood-vessels and amnion. The freeend of the cord is rich in round cells, appearing much like thegranulation tissue of healing wounds. At this point the end No. i.] ORIGIN OF HUMAN MONSTERS. 159 of the cord is infiltrated with cells, in addition to the nu-cleated cells of the cord, and it has very ragged edges. Itappears as if the embryo had gradually fallen off, piece bypiece, leaving the ragged stump of a cord. The blood-vesselsof the cord are but sparsely filled with blood. At the base
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