Transactions of the Royal Society of Edinburgh . es of gout, but itsaction on the liver has not hithertobeen tested by direct grains of the extract is themaximum dose for a man. Experiment 16. Dog that hadfasted sixteen hours. Weight 23*5kilogrammes.—Sixty grains of theaqueous extract of colchicum of theBritish Pharmacopoeia in 10 cc. of water were injected into the duodenum(c, fig. 16). In an hour the biliary secretion began to increase, and five hoursafter the injection it was nearly five times more than before the drug wasgiven. The secretion then fell, and just at the close


Transactions of the Royal Society of Edinburgh . es of gout, but itsaction on the liver has not hithertobeen tested by direct grains of the extract is themaximum dose for a man. Experiment 16. Dog that hadfasted sixteen hours. Weight 23*5kilogrammes.—Sixty grains of theaqueous extract of colchicum of theBritish Pharmacopoeia in 10 cc. of water were injected into the duodenum(c, fig. 16). In an hour the biliary secretion began to increase, and five hoursafter the injection it was nearly five times more than before the drug wasgiven. The secretion then fell, and just at the close of the experiment a VOL. XXIX. PART I. 2 T Experiment 16. Secretion Secretion Secretion of bile per Secretion of bile per of bile per kilogramme of bile per kilogramme 15. of dog: per 15. of dog: per hour. hour. cc. cc. 1-07 1 0138 cc. 1-25 V 0-246 cc. 0-92 0-5 077 1-651-451-45 c 1-7 1 0-371 cc. 1-02 1-0 07 1 0-207 cc. 2-252-222-55 1-15 i 2-65 ^ 1-25 1-1 1-05 10-227 cc. 2-72-52-8 V 0-453 cc. 0-95 J 1-36 2-0 1-5 162 PROFESSOR RUTHERFORD ON THE. Fit 17.—Secretion of bile before and after 60 grains of aqueous extractof colchieum in 10 cc. of water were injected into duodenum at c. large quantity of liquid frcces was discharged. The rise in the curve infig. 16 suggests a very powerful stimulation of the liver, but it must beremembered that the animal was of large size, and the table of numbersshows that the secretion per kilogramme of dog never went higher than0 453 cc. Neckopsy.—There was great vascularity of the upper four-fifths of the mucous membrane of thesmall intestine. The vas-cularity of the duodenumwas intense. The mucousmembrane of the largeintestine was also unusu-ally vascular. The gastricmucous membrane waspale. There was evidenceof considerable hydroca-tharsis in the small in-testine. The large intes-tine was empty, owing tothe recent discharge offaecal matter. Experiment 17. Dog thathad fasted eighteen 236 kilogrammes.—Sixty grains of aqueousext


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