Cancer of the stomach; a clinical study of 921 operatively and pathologically demonstrated cases . ssible. The relation existing betweenvolume of epitheHal cells and connective tissue determinesthe cHnical type of tumor resulting. It furnishes the basisof a rough histologic grouping. (6) Hyperplasia of the extraglandular structures con-stitutes evidences of tissue resistance. It is grossly a localindex of the strength of the stomachs defensive may be vigorous during the early stages of theulcerative process and then apparently become negligible, MORBID ANATOMY 91 or, late in the d
Cancer of the stomach; a clinical study of 921 operatively and pathologically demonstrated cases . ssible. The relation existing betweenvolume of epitheHal cells and connective tissue determinesthe cHnical type of tumor resulting. It furnishes the basisof a rough histologic grouping. (6) Hyperplasia of the extraglandular structures con-stitutes evidences of tissue resistance. It is grossly a localindex of the strength of the stomachs defensive may be vigorous during the early stages of theulcerative process and then apparently become negligible, MORBID ANATOMY 91 or, late in the development of a rapidly advancing ulcer,energetic resistance may be put forth and the processstopped. As we have stated, in the early stages of simple ulcer,hyperplasia is most active in the glands of the edges. Thisincrease causes overhanging borders. There is fre-quently a similar hyperplasia in the base. Tissue resistanceis manifested by an abundant infiltration of small lympho-cytes. Not infrequently polynuclear leucocytes are alsopresent. The hyperplastic gland process is thus well walled. Fig. 44.—(Case No. 94,647).—Same tissue as in Fig. 43, showing cellsfreely discharging mucin; spherical nuclei.—(Wilson.) off. There is little evidence of vascularization. Surfacenecrosis often keeps pace with the epithelial hyperplasia—the sloughing thereby giving the ulcer a characteristiccrater-like form. In instances of moderate activity, thegland hyperplasia is checked apparently by the leucocyteinvasion. Hyperplasia of scar tissue then occurs, andtypical, protected, callous ulcer results. If, however, asource of stimulation keeps the epithelial hyperplasiaactive, and if the process becomes moderately extensive,the hypertrophied glandj^tubules push aside the con- 92 CANCER OF THE STOMACH nective-tissue cells and diminish the number of avenuesalong which protective cells or fluids may be conveyed to
Size: 1786px × 1398px
Photo credit: © The Reading Room / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookdecade1910, bookpublisherphiladelphialondon
